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血浆中性粒细胞弹性蛋白酶与冠状动脉病变形态学特征的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第4期
页码:
353-355
栏目:
临床研究
出版日期:
2005-09-05

文章信息/Info

Title:
The relationship between the plasma neutrophil elastase levels and angiographic morphology of coronary lesions
作者:
安家晨; 曾秋棠; 曹林生; 冯义柏; 王祥; 李大主
华中科技大学同济医学院附属协和医院心内科, 湖北 武汉 430022
Author(s):
AN Jiachen;  ZENG Qiutang;  CAO Linsheng;  FENG Yibai;  WANG Xiang;  LI Dazhu
Department of Cardiology, Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
关键词:
冠状动脉疾病; 冠状动脉造影术; 中性粒细胞弹性蛋白酶
Keywords:
coronary disease;  coronary angiography;  neutrophil elastase
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血浆中性粒细胞弹性蛋白酶（neutrophil elastase，NE）与冠状动脉病变形态学的关系。方法 根据冠状动脉造影结果对88例观察对象进行分组：①按照冠状动脉病变形态特征分为：简单病变组，复杂病变组。②按照冠状动脉病变范围分为：单支病变组，多支病变组。③按照冠状动脉病变程度（Gensini积分法）分为：轻度病变（A组），重度病变（B组）。用ELASA法检测血浆NE含量，比较不同组间NE含量变化。结果 血浆NE含量 复杂病变组高于简单病变组及正常对照组，差异有显著性意义（P<0.01）。多支病变组高于单支病变组，B组高于A组，差异均有显著性意义（P<0.01）。结论 血浆NE含量与冠状动脉病变稳定性、病变范围及程度相关。
Abstract:
AIM To investigate the correlation between the plasma neutrophil elastase (NE) levels and angiographic morphology of coronary artery lesions. METHODS 88 subjects were divided into different groups based on coronary angiography. ① According to the shape of coronary artery lesions they were divided into simple lesions group and complex lesions group. ②According to the area of coronary artery lesions they were divided into singlebranch lesions group and multibranches lesions group. ③According to the severity of coronary artery lesions (Gensini scoring system) they were divided into slight lesions group (A group) and serious lesions group (B group). Plasma NE levels were determined by ELASA, and then they were compared between the groups. RESULTS Plasma NE levels was significantly higher in patients with complex lesions group than those in patients with simple lesions group and normal healthy control group (P<0.01),and was higher in multibranches lesions group than in singlebranch lesions group (P<0.01), and was higher in serious lesions group than in slight lesions group (P<0.01). CONCLUSION Plasma NE levels are related with the stability, severity and area of coronary lesions.

参考文献/References

［1］Bauriedel G, Hutter R, Welsch U, et al. Role of smooth muscle cell death in advanced coronary primary lesions: implications for plaque instability［J］. Cardiovasc Res, 1999,41(2): 480-488.

［2］Amaro A, Gude F, GonzalezJuanatey R, et al. Plasma leukocyte elastase concentration in angiographically diagnosed coronary artery disease［J］. Eur Heart J, 1995,16(5): 615-622.

［3］Ross R. Atherosclerosis—an inflammatory disease［J］. N Engl J Med,1999,340: 115-126.

［4］张剑，韩雅玲，康建，等．纤维蛋白原与冠心病类型、危险因素及病变的相关性［J］．心脏杂志，2003，15（2）：326-330．

［5］陈 皓，李源，王晓明. 可溶性P选择素与急性冠脉综合征的关联性［J］．心脏杂志，2003，15（4）：134-136．

［6］王兴祥，周利龙，冯义柏，等. C反应蛋白与冠状动脉病变的相关性及其临床意义［J］．心脏杂志，2002，14（6）：485-487．

［7］Maciejewski R, Madej B, Draus J, et al. Elastase activity and histological changes in lungs and pancreas due to experimental pancreatitis［J］. Folia Hstochem Cgtobiol, 1999, 37(2):103.

［8］Fujie K, Shinguh Y, Yamazaki A, et al. Inhibition of elastase induced acute inflammation and pulmonary in hamsters by a novel neutrophil elastase inhibitor FR901277［J］. Inflamm Res, 1999,48(3) :160.

［9］Bedard M, Mcclared CD, Schiller NL.Release of interleukin8, interleukin6 and colocy stimulating factors by upper airway epithelial cells: implications for cystic fibrosis［J］. Am J Respair Call Md Bid , 1993,9:141-144.

［10］任冰稳，白晓军，马爱群. 急性冠状动脉与基质金属蛋白酶 ［J］. 临床心血管病杂志，2002，18:413-415.

［11］Plutzky J. Atherosclerotic plaque rupture: Emerging insights and opportunities［J］. Am J Cardiol, 1999, 84(1A): 15J-20J.

［12］Fukuda D, Kawarabayasi T,Tanaka A,et al. Lesion characteristics of acute myocardial infartion: An investigation with intravascular ultrasound［J］. Heart,2001,85:402-406.

［13］Masakaza Y, Mitsuyasu T, kojiro A,et al. Morphology vulnerable coronary plaque: Insights from follow up of patients examined by intravascular ultrasound before an acute coronary syndrome［J］. Am J Coll Cardiol, 2000,35:106-111.

［14］Kosar F, Varol E, Ayaz S,et al .Plasma leukocyte elastase concentration and coronary artery disease ［J］. Angiology， 1998, 49(3):193-201.

备注/Memo

备注/Memo:
收稿日期：2004-04-02.
更新日期/Last Update: 2010-01-05