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Title:: Effect of Qidan Tongmai tablet on cardiac function in a mouse model of myocardial infarction

作者:: 李晶华¹; 邵中军²; 肖铁卉¹; 王宗仁¹; 张磊²; 马静¹; 第四军医大学：1.西京医院中医科，2.预防医学系流行病学教研室，陕西西安 710032

Author(s):: LI Jinghua¹; SHAO Zhongjun²; XIAO Tiehui¹; WANG Zongren¹; ZHANG Lei²; MA Jing¹; 1. Department of Traditional Chinese Medicine, Xijing Hospital, 2. Department of Epediemiology, Fourth Military Medical University, Xi′an, Shaanxi 710032, China

关键词:: 心功能; 芪丹通脉片; 心肌梗塞

Keywords:: cardiac function; Qidan Tongmai tablet; myocardial infarction

分类号:: R972;R542.22

DOI:: -

文献标识码:: A

摘要:: 目的探讨预防性芪丹通脉片（QDTMT）对梗死心肌的左室功能保护作用。方法 SD大鼠分为对照组、模型组、QDTMT组。通过结扎冠状动脉左前降支（LAD）复制缺血模型，生理仪记录左室功能。结果 QDTMT能明显降低排血前时间，等容收缩时间，排血前时间/左室射血时间和等容收缩时间/左室射血时间。结论芪丹通脉片对缺血大鼠左心室功能具有保护作用。

Abstract:: AIM To observe protective effects of Qidan Tongmai tablet (QDTMT) on cardiac function after myocardial infarction. METHODS SD mice were randomly divided into control group, model group and QDTMT group. Myocardial infarction model was constructed by ligation of coronary artery left anterior descending branch. The polygraphy was employed to record the left ventricular function. RESULTS QDTMT could decrease preejection period (PEP), preejection period/left ventricular ejection time (P/L), isovolumic contraction time (ICT) and isovolumic contraction time/left ventricular ejection time (I/L). CONCLUSION QDTMT exerts beneficial effects on cardiac function after myocardial infarction.

参考文献/References

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［2］吴旭,赵忠. 蜕皮甾酮对大鼠心肌再灌注诱发心律失常的影响［J］. 解放军药学学报,2002,18(1):1-3.

［3］李延忠,纪凤兰,张殿文,等. 心宁片的心血管作用研究［J］. 中药药理与临床,2004,20(2):38-39.

［4］戴瑞鸿,李勇. 冠心病心肌缺血的治疗性血管生成中药［J］. 中国中西医结合杂志，2000,20(3):163-164.

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芪丹通脉片对实验性急性心肌梗死大鼠左心室功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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