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原发性高血压不同危险度分层中血管活性物质的水平及药物治疗的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第6期
页码:
536-538
栏目:
基础研究
出版日期:
2005-12-05

文章信息/Info

Title:
Content of plasma vasoactive substances in hypertensive patients with different risk stratifications and the influence of medicine
作者:
倪宁1; 王建智2; 巨安丽3; 翁改志1; 刘江1; 宋燏1
1. 西安交通大学医院内科，陕西 西安 710049; 2. 中国东方航空公司西北公司飞行部航空卫生科，陕西 西安 710082; 3. 西北工业大学医院内科，陕西 西安 710072
Author(s):
NI Ning;  WANG Jianzhi;  JU Anli; WENG Gaizhi;  LIU Jiang; SONG Yu
1. Department of Internal Medicine, Hospital of Xi′an Jiao Tong University,Xi′an,Shaanxi 710049,China; 2. Department of Aviation Medicine, Westnorth Voyage Unit , East Airline Company, China,
关键词:
高血压; 原发性; 肾上腺髓质素; 内皮素-1; 假性血友病因子; 心房钠尿肽
Keywords:
essential hypertension;  adrenomedullin;  endothelin1;  Von willebrand factor;  atrial natriuretic peptide
分类号:
R541.3
DOI:
-
文献标识码:
A
摘要:
目的 观察原发性高血压患者不同危险度分层的血浆肾上腺髓质素（ADM）、内皮素-1（ET1）、假性血友病因子（VWF）及心房钠尿肽（ANP）的水平及临床意义。方法 随机选取不同危险度分层的原发性高血压患者100例。30例正常人对照。测定血管紧张素转换酶抑制剂（ACEI）治疗前后血浆ADM、ET1、VWF、ANP浓度的变化。ADM、ET1、ANP采用放免分析法，VWF采用酶联免疫法。结果 治疗前各组与对照组比较，ADM、ET1、VWF、ANP显著升高（P<0.05或P<0.01）。治疗后各组ADM、VWF、ET1、ANP显著降低（P<0.01）。结论 ADM、ET1、VWF、ANP与原发性高血压危险度分层相关。通过治疗可降低ADM、ET1、VWF、ANP的水平，改善内皮功能。
Abstract:
AIM To observe the content of plasma adrenomedullin (ADM), endothelin1(ET1), von willebrand (VWF), atrial natriuretic peptide (ANP)in essential hypertension (EH) patients with different risk stratifications and to explore the clinical significance . METHODS One hundred hypertensives were randomly selected and divided into 4 groups: low risk group (n=26), medium risk group(n=23), high risk group (n=24) and highest risk group(n=27). Thirty normal subjects were recruited as the control group. ADM, ET1, VWF, ANP were measured before and after ACEI treatment. The levels of plasma ADM, ET and ANP were determined by radio immunoassay, and VWF by ELISA. RESULTS Before treatment, the plasma levels of ADM, ET1, VWF and ANP in EH patients were significantly different from those in normal subjects (P<0.01 or P<0.05). There were significant decreases in ADM, ET1 VWF, ANP were significantly different among different groups of EH subjects (P<0.01). ADM, ET1 and ANP after treatment. CONCLUSION ADM, ET1, VWF and ANP were related with the different risk stratification in essential hypertension. The effective treatment could decrease the levels of ADM, ET1, VWF and ANP to improve endothelial function.

参考文献/References

［1］ Chalmers J, Hanehira T, Virdis A, et al. WHOISH hypertension guidelines committee. 1999 World health organizationinternational society of hypertension guidelines for the management of hypertension［J］. Hypertension, 1999, 17: 151-185.

［2］ Lip GYH, Blann AD. Von Willebrand factor; a marker of endothelial dysfunction in vascular disorder?［J］. Cardiovasc Res, 1997, 34: 225-228.

［3］ Pedrinelli R, Giampietro O, Carmassi F, et al. Microalbuminuria and endothelial dysfunction in essential hypertension［J］. Lancet, 1994, 344:14.

备注/Memo

备注/Memo:
收稿日期：2005-05-30.作者简介：倪宁，主治医师，硕士Tel：（029）82668466 Email：stpuma63@163.com
更新日期/Last Update: 2010-01-06