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冠脉内支架置入术后IL6与IL10的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第6期
页码:
559-560,563
栏目:
临床研究
出版日期:
2005-12-05

文章信息/Info

Title:
Changes of serum interleukin6 and interleukin10 after coronary stent implantation
作者:
周艳芳;  陈晓春; 葛智平
内蒙古医学院第三附属医院心内科 ，内蒙古 包头 014010
Author(s):
ZHOU Yanfang; CHEN Xiaochun;  GE Zhiping
Department of Cardiology, Third Affiliated Hospital，Medical College of InnerMongolia , Baotou,Inner Mongolia 014010, China
关键词:
冠状动脉疾病;  支架;  细胞因子; 再狭窄
Keywords:
coronary disease;  stent;  cytokines;  restenosis.
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
目的 研究冠脉内支架置入术后IL6和IL10在外周血中的变化及临床意义。方法 行冠脉内支架置入术后患者30例。取支架置入前和术后24 h股动脉血，检测血清IL6、IL10，并观察术中、术后并发症。结果 支架置入术后24 h外周血IL6显著高于术前（215±118 pg/ml vs 176±82 pg/ml，P<0.05），而IL10较术前稍有下降但无统计意义（P>0.05），术后IL6/IL10比值较术前显著升高（3.3±1.9 vs 2.3±1.0， P<0.05）。伴并发症及再狭窄者较无并发症及再狭窄者术后IL6、IL6/IL10比值均显著升高（分别为302±157 pg/ml vs 193±99 pg/ml, P<0.05；5.4±2.0 vs 2.7±1.5， P<0.01）。结论 冠脉内支架置入后引起IL6和IL6/IL10比值显著增加，IL6及IL6/IL10比值增加可能与支架术后心血管并发症和再狭窄的发生有一定关系。
Abstract:
AIM To investigate the changes of proinflammatory cytokines interleukin6(IL6) and antiinflammatory cytokines interleukin10(IL10) in the peripheral circulation after coronary stent implantation. METHODS The study involved 30 patients who underwent coronary artery stent implantation. Blood samples were taken from the femoral arterial blood before and 24 h after coronary stenting. Serum levels of interleukin 6 (IL6) and interleukin 10 (IL10) were measured and complications were observed. RESULTS The level of IL6 in femoral arterial blood was significantly increased 24 h after implantation(215±118 pg/ml vs 176±82 pg/ml, P<0.05) , while IL10 level was slightly decreased with no significant difference. IL6/IL10 ratio was markedly increased （3.3±1.9 vs 2.3±1.0, P<0.01）. In patients with restenosis or cardiovascular complications, IL6 level (302±157pg/ml vs 193±99 pg/ml ,P<0.05) and the ratio of IL6/IL10 (5.4±2.0 vs 2.7±1.5, P<0.05) were significantly higher than in those without these conditions. CONCLUSION Stentimplantationinduced elevation of IL6 and IL6/IL10 ratio may contribute to the complications and restenosis after coronary stent implantation.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-11-30.通讯作者：陈晓春,主任医师，硕士,主要从事冠心病诊治方面的研究Tel：（0472）5992714 作者简介：周艳芳，主治医师,硕士生 mail:xyj24@sina.com
更新日期/Last Update: 2010-01-06