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高睾酮血症对去势高脂雄兔早期动脉硬化的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第1期
页码:
11-13
栏目:
基础研究
出版日期:
2006-01-01

文章信息/Info

Title:
Hypertestosteronemia aggravate early atherosclerosis of coronary artery in castrated and cholesterolfed male rabbits
作者:
王蓉; 范利; 李小鹰; 武强
解放军总医院南四科, 北京 100853
Author(s):
WANG Rong;  FAN Li;  LI Xiao-ying;  WU Qiang
General Hospital，People’s Liberation Army，Beijing 100853, China
关键词:
雄激素; 睾酮; 动脉粥样硬化; 血脂
Keywords:
androgen; testosterone;  atherosclerosis; lipids
分类号:
R711.5;R543.5
DOI:
-
文献标识码:
A
摘要:
目的 研究高睾酮血症对去势高脂饮食雄性家兔早期动脉硬化的影响，为雄激素在临床合理应用提供理论依据。方法 制备高脂并高睾酮血症的雄兔模型，12周后测定雄兔血脂、载脂蛋白水平；观察并测量冠状动脉及肾动脉的内膜厚度。结果 高睾酮血症组血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、LDL-C/HDL-C、apoB/apoA1显著高于假手术组和生理水平组（P<0.01）；高睾酮血症组冠状动脉早期动脉硬化的程度重于假手术组和生理水平组（P<0.05）。结论 高睾酮血症对于去势高脂饮食雄兔冠状动脉早期动脉硬化有促进作用。
Abstract:
AIM To determine the influence of different levels of serum testosterone on early atherosclerosis of coronary artery in castrated rabbits on cholesterolrich diet. METHODS Thirty white adult New Zealand male rabbits were randomly assigned to three groups: control group, physiological group, hypertestosteronemia group. All animals were castrated (bilateral castration) and fed a cholesterolrich diet. Serum level of total testosterone and estradiol, serum lipids and lipoproteins were analyzed after twelve weeks. And samples of coronary and kidney arteries were carefully analyzed under histological observation. RESULTS Average serum TC、TG、LDLC、apoB、LDLC/HDLC、apoB/ apo A1 were higher in hypertestosteronemia group than in control group and physiological group (P<0.01). Histological analysis showed more intense changes of early atherosclerosis of coronary arteries in hypertestosteronemia group than in control group and physiological group（P<0.05）. CONCLUSION Hypertestosteronemia accelerates early atherosclerosis of coronary arteries in castrated rabbits on cholesterolrich diet.

参考文献/References

［1］Bagatell CJ, Bremner WJ.Androgens on men: uses and abuses［J］. N Engl J Med, 2001, 334:707-714.

［2］ Study group, European Atherosclerosis Society. The recognition and management of hyperlipidaemia in adults:a policy statement of the European Atherosclerosis Society［J］. Eur Heart J, 2000, 9:571-600.

［3］ 武强，李小鹰. 睾酮对去睾丸家兔血脂和载脂蛋白的影响［J］.中国应用生理学杂志,2003,19:1-3.

［4］ 聂永梅，成敏，陈槐卿,等. 动脉粥样硬化进程中血脂、血流动力学指标和血管内膜的动态变化［J］. 生物医学工程学杂志,2005,22:10-14.

［5］ Ross R.The pathogenesis of atherosclerosis: A perspective for the 1990［J］. Nature, 2000,362:801-806.

［6］ Fujimoto R,Morimoto J, Martia E, et al. Androgen receptors, 5 alphareductase activity and androgendependent proliferation of vascular smooth muscle cells［J］. J Steroid Biochem Mol Biol, 2001,50:169-174.

［7］ McCrohon JA,Peath AK,Nakhla S,et al. Androgen receptor expression is greater in macrophages from male than from female donors［J］. Circulation, 2000,101:224-226.

［8］ 王蓉，范利. 睾酮对动脉粥样硬化的影响及机理［J］. 国外医学·心血管疾病分册,2004, 31:158-160.

［9］ Sorva R, Kausi T, Taskinen MR, et al. Testosterone substitution increases the activity of lipoprotein lipase and hepatic lipase in hypogounadal males［J］. Atherosclerosis, 2001,69:191-197.

［10］刘昌慧，陶琳. 脂蛋白(a)与冠心病的关联性［J］.心脏杂志,2004,16:294.

备注/Memo

备注/Memo:
收稿日期：2005-05-27.基金项目：全军“十五”重大临床技术研究项目资助（2002卫医字第18号）作者简介：王蓉，主治医师,硕士 Tel：（010）66937494 Email：wangrong1208@yahoo.com.cn
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