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Title:: Hyperhomocysteinemia as a risk factor for stroke and coronary disease: a casecontrol followup study

作者:: 叶辉¹; 邵娇梅²; 蒋键刚²; 赵春霞²; 张帆²; 汪道文²; 1. 深圳市第二人民医院内科12病区，广东深圳 518035；2. 华中科技大学同济医学院附属同济医院心血管内科，湖北武汉 430030

Author(s):: YE Hui; SHAO Jiao-mei; JIANG Jian-gang; ZHAO Chun-xia; ZHANG Fan ; WANG Dao-wen; Department of Internal Medical, Second People′s Hospital，Shenzhen, Guangdong 518035，China

关键词:: 同型半胱氨酸; 冠状动脉疾病; 脑卒中; 危险因素

Keywords:: homocysteinemia; coronary artery disease; stroke; risk

分类号:: R541.4;R743.3

DOI:: -

文献标识码:: A

摘要:: 目的研究血同型半胱氨酸水平与心脑血管疾病的关系。方法随机收集173 例高同型半胱氨酸血症患者，并按年龄、性别相匹配收集173例健康对照人群，进行1年随访。观察冠心病及脑卒中发病与高同型半胱氨酸血症的关系。结果高同型半胱氨酸血症组3.6%例发生冠心病 (其中有心肌梗死2例), 明显高于对照组0.6%(RR为3.0，95% CI: 0.4-5.5,P<0.05), 高同型半胱氨酸血症组4.1%例发生脑卒中也明显高于对照组0.6%（RR为3.5，95% CI: 0.7-6.4, P<0.05), 高同型半胱氨酸血症组有7.7%例发生冠心病及脑卒中明显高于对照组1.2%（RR为6.4，95% CI: 2.7-10.1,P<0.01)。结论高同型半胱氨酸血症是心脑血管疾病的一个危险因素。

Abstract:: AIM To examine whether an elevation of total plasma homocysteine is a risk factor for coronary heart disease and stroke. METHODS The study involved 173 patients with hyperhomocysteinemia and selected healthy subjects of matching age and sex. The incidence of coronary disease and stroke was observed during the oneyear follow up. RESULTS The incidence of coronary disease was 3.6% in hyperhomocysteinemia patients and 0.6% in the control（RR:3.0，95% CI: 0.4 to 5.5, P<0.05）, and that of stroke was 4.1% in the patients and 0.6% in the control（RR:3.5，95%CI:0.7 to 6.4, P<0.05）. Both coronary disease and stroke occurred in 7.7% of the patients, while in 1.2% of the healthy subjects ( RR:6.4, 95% CI:2.7 to 10.1, P<0.01). CONCLUSION Hyperhomocysteinemia is a risk factor for coronary disease and stroke.

参考文献/References

［1］ Herrmann W. The importance of hyperhomocysteinemia as a risk factor for diseases: an overviw［J］. Clin Chem Lab Med, 2001,39(8):666-674.

［2］ Blundell G, Jones BG, Rose FA, et al. Homocysteine mediatedendothelial cell toxicity and its amelioration ［J］. Arteriosclerosis, 1996,122(2):201-216.

［3］唐梦熊,黄文增,张步延，等. 血浆同型半胱氨酸对冠心病患者血管内皮功能的影响［J］.心脏杂志,2002,14(4):305-306.

［4］田青平,刘乃奎，汤键，等. 同型半胱氨酸促进平滑肌细胞增殖的内信号传递途径［J］. 中华医学杂志，2000，80（2）：152-154.

［5］Sparrow CP, Olszewski J. Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metalions ［J］. J Lipid Res, 1993,34(7):1219-1228.

［6］Stamlen JS, Osborn JA. Adverse affects of homocysteine are modulated by endothelium derived relaxing factor and related oxides of nitrogen ［J］. J Clin Invest, 1993,91:308-318.

［7］ Tanne D, Haim M, Goldbourt U, et al. Prospective study of serum homocysteine and risk of ischemic stroke among patients with preexisting coronary heart disease ［J］. Stroke, 2003,34(3):632-636.

［8］闫韵洪,张利华. 同型半胱氨酸与冠状动脉粥样硬化的相关性［J］. 心脏杂志,2002,14(4):303-304.

［9］ Howard VJ, Sides EG, Newman GC, et al. Changs in plasma homocysteine in the acute phase after stroke ［J］. Stroke, 2002,33(2):473-478.

［10］叶辉，严江涛，邵娇梅，等. 血浆同型半胱氨酸水平及亚甲基四氢叶酸还原酶基因突变与脑卒中关系的病例对照研究［J］. 中华流行病学杂志,2004,25(11):958-961.

［11］Bos MJ, van Goor ML, Koudstaal PJ, et al. Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischaemic stroke or TIA ［J］. J Neurol,2005,252(3):332-337.

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血同型半胱氨酸与心脑血管疾病关系随访研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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