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Title:: Beneficial effects of simvastatin on acute coxsackievirus B3 murine myocarditis

作者:: 龚志刚¹; 苏东东²; 丁世芳¹; 付文波¹; 包明威³; 蔡军³; 广州军区武汉总医院：1.心内科, 2.门诊湖北武汉 430070; 3.武汉大学人民医院心内科, 湖北武汉 430060

Author(s):: GONG Zhi-gang¹; SU Dong-dong²; DING Shi-fang¹; FU Wen-bo¹; BAO Ming-wei³; CAIJun³; 1.Department of Cardiology, 2.Outpatient Department, Wuhan General Hospital, Wuhan， Hubei 430070,China. 3.Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan,Hubei 430060，China

关键词:: 辛伐他汀; 病毒性心肌炎; 病毒滴度; 疗效

Keywords:: simvastatin; viral myocarditis; virus titer; effect

分类号:: R542.2

DOI:: -

文献标识码:: A

摘要:: 目的探讨辛伐他汀对急性柯萨奇B3病毒感染小鼠心肌早期的作用。方法将柯萨奇B3病毒感染小鼠随机分为两组：对照组(n=15)及辛伐他汀治疗组（n=15），分别给予生理盐水及辛伐他汀14 d。第6天时，各组分别随机处死6只。结果辛伐他汀治疗组其心脏质量(69±13mg) 较对照组(96±16mg) 减轻（P<0.01）；心肌炎症及坏死程度减轻，心肌病理积分(8.0%±7.3% vs 22.9%±10.6%) 显著降低（P<0.01）；14 d生存率明显升高（P<0.05）。结论辛伐他汀治疗可减轻心肌病理损害，对早期感染柯萨奇B3病毒小鼠心肌有保护作用。

Abstract:: AIM To elucidate the effect of HMGCoA reducatase inhibitor on the early stage of viral myocarditis. METHODS Mice were infected with coxasckievirus B3 and divided into two main protocols. Mice in the treated protocol (n=15) were treated on day 1 after infection with either simvastatin or saline through day 14 of infection and six mice at random from each group were killed on day 6 of infection. RESULTS Heart mass was 69 ±13 mg in the simavastatintreated group vs 96±16 mg in the control group (P<0.01). The degree of inflammation, necrosis, and dystrophic calcification assessed with a semiquantitative histological score was significantly less in the simvastatintreated group. The degree of pathological involvement determined by planimetry of histological sections was （8.0± 7.3）% for the simvastatintreated group vs （22.9 ±10.6）% for the salinetreated group (P<0.01). The 14day survival rate of simvastatintreated group was higher than that of the control group(P<0.05). CONCLUSION Simvastatin is beneficial in acute coxsckievirus B3 murine myocarditis because it reduces heart mass and necrosis when administered early.

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辛伐他汀对柯萨奇B3病毒感染小鼠心肌早期的保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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