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左旋卡尼汀对犬心房急性电重构的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第3期
页码:
284-285,292
栏目:
基础研究
出版日期:
2006-06-25

文章信息/Info

Title:
Effects of L-carnitine on acute atrial electrical remodeling in dogs
作者:
闫俊瑾; 王玉堂; 单兆亮; 时向民; 周俊彦; 国建萍
解放军总医院心内科，北京 100853
Author(s):
YAN Jun-jin;  WANG Yu-tang;  SHAN Zhao-liang;  SHI Xiang-min;  ZHOU Jun-yan;  GUO Jian-ping
Department of Cardiology, General Hospital of PLA, Beijing 100853, China
关键词:
心房颤动; 电重构; 左旋卡尼汀; 犬
Keywords:
atrial fibrillation;  electrical remodeling;  L-carnitine;  dog
分类号:
R541. 75
DOI:
-
文献标识码:
A
摘要:
目的 观察左旋卡尼汀（L-carnitine, L-CN）对犬心房颤动（房颤）所引发心房急性电重构的预防作用。方法 12只犬随机分为L-CN组和生理盐水对照组。以800次/min的频率快速起搏右心房1 s以诱发短阵房颤，在恢复窦性心律即刻重复发放刺激以维持房颤 2 h。观察各组房颤前后不同时间段的右心房有效不应期（AERP）、AERP的频率适应性及右心房内传导速度（CV）的变化。结果 房颤后盐水组AERP显著缩短（P<0.05），L-CN组房颤前后AERP无显著缩短；盐水组的AERP的频率适应性显著下降（P<0.05），L-CN组该指标无显著变化；房颤前后两组间右心房内CV无明显改变。结论 L-CN能够有效防止房颤诱发的心房急性电重构。
Abstract:
AIM To evaluate the effects of Lcarnitine (LCN) on tachycardiainduced acute atrial electrical remodeling in dogs. METHODS Twelve dogs were randomly divided into normal saline (NS) group and L-CN group. Right atrium was paced at 800 bpm for 1s to induce atrial fibrillation (AF) and the AF was maintained for 2 hours by rapid pacing as soon as sinus rhythm restored. The atrial effective refractory period (AERP), the AERP rate adapting feature and the rightatrium conduction velocity (CV) before and 2 hours after AF were measured at basic pacing cycle length of 200 ms. RESULTS The AERP shortened dramatically 2 hours after AF ( P<0.05) in NS group and it showed no remarkable change in L-CN group. (AERP200AERP150)/50 ms in the right atrium decreased significantly (P<0.05) in NS group but it did not change in LCN group. No significant change of right atrial CV was found before and 2 hours after AF in the two groups. CONCLUSION L-CN prevents tachycardiainduced acute atrial electrical remodeling in dogs.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-01-09.基金项目：全军医学科研"十五"计划项目资助（No.01MB074） 通讯作者：王玉堂，主任医师，主要从事心脏起搏与电生理研究 Tel: (010)66937451 Email:wyt301@sina.com 作者简介：闫俊瑾，住院医师，硕士，现在北京朝阳医院心脏中心 Tel：(010)51718648 Email:yjj0720@sina.com
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