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急性冠脉综合征患者外周血MMP-9及CRP的变化及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第3期
页码:
318-319,322
栏目:
临床研究
出版日期:
2006-06-25

文章信息/Info

Title:
Changes and implication of peripheral blood levels of matrix metalloproteases9 and Creactive protein in patients with acute coronary syndromes
作者:
殷忠; 李兰荪; 张荣庆; 刘安恒; 栾荣华; 王海昌
第四军医大学西京医院心内科，陕西 西安 710033
Author(s):
YIN Zhong;  LI Lan-sun;  ZHANG Rong-qing;  LIU An-heng;  LUAN Rong-hua;  WANG Hai-chang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi′an，Shaanxi 710032, China
关键词:
急性冠脉综合征; 心肌梗塞; 急性; 不稳定型心绞痛; 稳定型心绞痛; 基质金属蛋白酶-9; C反应蛋白
Keywords:
acute coronary syndromes; myocardial infarction; acute; unstable angina; stable angina; matrix metalloprotease-9; C-reactive protein
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察急性冠脉综合征（ACS）患者外周血中基质金属蛋白酶-9（matrix metalloproteases-9，MMP-9）及C反应蛋白（CRP）的水平变化，探讨MMP-9、CRP与ACS发生的关系。方法 选取ACS患者39例，采用双抗体夹心ELISA测定血清MMP-9的水平，CRP用免疫散射比浊法检测。结果 ACS患者入院即刻血浆MMP-9 、CRP水平均显著高于对照组［（66±16) vs (24±11) μg/L，P<0.01；(12.3±9.2) vs (3.5±2.0) mg/L，P<0.01］。 ACS组内UA亚组与AMI亚组比较，MMP9水平显著增高［（78±11) vs (50±14） μg/L，P<0.01］，而CRP水平显著下降［（7.2±2.2) vs (18.7±10.7) mg/L，P<0.01］。ACS组患者中MMP9和CRP水平无明显相关性。结论 冠心病患者外周血MMP-9、CRP水平升高。ACS患者中MMP-9和CRP水平无明显相关性。
Abstract:
AIM To investigate whether peripheral blood levels of matrix metalloproteases-9 (MMP-9) and Creactive protein（CRP）are affected in patients with acute coronary syndromes (ACS). METHODS Using enzymelinked immunosorbent assay (ELISA) and scatter rate nephelometry, serum MMP-9 and CRP were measured in 39 patients with ACS. RESULTS The serum levels of MMP-9 and CRP in ACS group were significantly higher than those in control groups (P<0.01). In ACS group, the serum level of MMP-9 was higher in UA subgroup than that in AMI subgroup (P<0.01) and CRP was higher in AMI subgroup than that in UA subgroup (P<0.01). But no significant correlation was found between MMP-9 and CRP in ACS group. CONCLUSION The serum levels of MMP-9 and CRP in patients with coronary artery disease increase and there is no correlation between MMP-9 and CRP.

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备注/Memo

备注/Memo:
收稿日期：2005-08-03.通讯作者：李兰荪，主任医师，教授，主要从事冠心病的诊断及治疗研究 Tel：（029）84775563 作者简介：殷忠，住院医师，硕士生 Tel：(029)82554077 Email：ouandyin@fmmu.edu.cn
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