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|本期目录/Table of Contents|

C反应蛋白与冠心病病变程度的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第3期
页码:
323-325
栏目:
临床研究
出版日期:
2006-06-25

文章信息/Info

Title:
Correlation between serum Creactive protein and severity of coronary artery disease
作者:
王文清; 宁波; 王新宴; 谈维洁; 李玲; 徐丽梅; 李丰
空军总医院涉外病区，北京100036
Author(s):
WANG Wen-qing;  NINGbo;  WANG Xin-yan;  TAN Wei-jie;  LI Ling;  XIU Li-mei;  LI Feng
Department of VIP, Air Force General Hospital, Beijing 100036, China
关键词:
C反应蛋白; 冠状动脉疾病; 相关性
Keywords:
c-reactive protein;  coronary disease; association
分类号:
R341.4;R543.3
DOI:
-
文献标识码:
A
摘要:
目的 研究C反应蛋白（CRP）与冠心病病变程度的关系。方法 测定经冠状动脉造影确诊的98例冠心病患者血浆CRP浓度。98例患者被分为3组：稳定型心绞痛组（n=32）、不稳定型心绞痛组（n=46）和急性心肌梗死组（n=20）；又根据血管病变程度分为单支血管病变组（n=56）及多支血管病变组（n=42）；同时以冠状动脉造影排除冠心病的23例患者作为对照组，比较各组间血浆CRP浓度。结果 冠心病患者各组CRP浓度均较正常对照组增高（P<0.05）。在冠心病各亚组中，不稳定型心绞痛组血浆CRP浓度高于稳定型心绞痛组，而急性心肌梗死组CRP浓度分别高于稳定型心绞痛和不稳定型心绞痛组（P<0.01）。多支血管病变组CRP含量更显著高于单支血管病变组（P<0.01）。结论 血浆CRP浓度与冠心病病变程度有密切关系。
Abstract:
AIM To assess the correlation of serum Creactive protein (CRP) and the severity of coronary artery disease (CAD). METHODS Ninetyeight cases diagnosed with CAD by coronary angiography (CAG) were divided into three groups: stable angina (32 cases), unstable angina (46 cases) and acute myocardial infarction (20 cases). Twentythree cases with normal angiography were used as the control. single injuries (56 cases) and complex injuries groups (42cases). The serum content of CRP was measured. RESULTS CRP was higher in the cases with CAD than in controls (P<0.05). The serum level of CRP was significantly higher in unstable angina group than in stable angina and the level of CRP in AMI group was markedly higher than the above 2 groups (P<0.00). In complex artery narrowing group, the CRP content was significantly higher compared with that with single artery injuries (P<0.01). CONCLUSION There is a close relationship between the serum level of CRP and the severity of coronary artery disease.

参考文献/References

［1］ Mehta JL, Saldeen TG,Rand K et al. Interaction role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease［J］. J Am Coll Cardial,1998,31(4):1217-1218.

［2］ Ridker PM. Clinical application of Creactive protein for cardiovascular disease detection and prevention ［J］. Circulation,2003,107(3):369-371.

［3］ Ridker PM, Morrow D. Highsensitivity Creactive protein and cardiovascular risk［J］. Am J Cardiol,2003,92(Suppl):17-22.

［4］ Pascri V.willerson JT,Yeh ETH. Direct proinflammatory effect of creactive protein on human endothelial cells［J］, Circulation,2000,102(18):2165-2168.

［5］ 李后开，戴敏. 内皮细胞炎症反应在动脉粥样硬化研究中的作用［J］. 中国动脉梗化杂志，2004，12（5）：607-610.

［6］ Tataru MC, Heinrich J, Junker R, et al. Creactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris［J］. Eur Heart J, 2000,21(3):1000-1002.

［7］ 陈协辉，陈晓君. 冠心病患者介入治疗前后血清C反应蛋白变化与心血管事件和再狭窄的关系［J］.中国综合临床，2005，21（9）：774-776.

［8］ 陈协辉，陈晓君.介入治疗对急性冠脉综合症血浆CRP影响的观察［J］.中国医师杂志，2004，6（12）：1692-1693.

［9］ Eren E, Yilmaz N, Pence S, et al. Diagnostic value of Creactive protein in patients with angiographically documented coronary heart disease［J］. Acta Medica, 2002,45(4):155-160.

［10］Nomoto K, Oguchi S, Watanabe I, et al, Involvement of inflammation in acute coronary syndromes assessed by levels of highsensitivity Creactive protein, matrix metalloproteinase9 and soluble vascularcell adhesion molecule1［J］. J Cardiol,2003,42(5):201-206.

［11］崔红玉.C反应蛋白在不同类型冠心病间的差异［J］. 心脏杂志，2005，17（6）：620.

［12］Yamashita H,Shimada K,Seki E, et al. Concentrations of inter leukins ,interferon ,and Creactive protein in stable and unstable angina pectoris ［J］. Am J Cardiol, 2003,91(2):133-136.

备注/Memo

备注/Memo:
收稿日期：2006-02-27.作者简介：王文清，主任医师，硕士 Tel：（010）66928422 Email：wwq6087@163.com
更新日期/Last Update: