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Title:: Changes and evaluation of inflammation markers in acute coronary syndrome

作者:: 魏玉杰¹; 刘惠亮¹; 何玉辉¹; 杨晓丽²; 武警总医院：1.心内科,2.检验科,北京 100039

Author(s):: WEI Yu-jie¹; LIU Hui-liang¹; HE Yu-hui¹; YANG Xiao-li²; 1.Department of Cardiology, 2.Clinical Laboratory, General Hospital of Chinese People′s Armed Police Forces, Beijing 100039, China

关键词:: 急性冠脉综合征; 血管细胞黏附分子-1; 血管性假性血友病因子

Keywords:: acute coronary syndrome; vascular cell adhesion molecule-1; von Willebrand Factor

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的探讨炎症标志物与急性冠脉综合征（ACS）的关系及临床意义。方法 ELISA测定22例急性心肌梗死（AMI）、37例不稳定型心绞痛（UAP）患者及对照组30例外周血可溶性血管间内皮细胞黏附分子（vascular cell adhesion molecule1,sVCAM-1）和血管性假性血友病因子（von Willebrand Factor，vWF）浓度，所有患者均行冠状动脉造影，记录血管病变情况。结果血清sVCAM1浓度在AMI组明显高于UAP组及对照组（P<0.01），UAP 组明显高于对照组（P<0.01）；血浆vWF浓度在AMI组与UAP组均显著高于对照组（P<0.01），但AMI组与UAP组比较无统计学意义；血清sVCAM-1与受累冠状动脉血管支数成正相关，r=0.450，P<0.01。而vWF水平与受累冠状动脉血管支数无相关关系，r=0.074。结论血清sVCAM1与冠状动脉病变程度密切相关，vWF与ACS的发生发展相关联。

Abstract:: AIM To investigate the relation of inflammation markers to acute coronary syndrome（ACS）and the clinical significance. METHODS The concentrations of serum sVCAM1 and vWF were assayed by ELISA and the severity of coronary atherosclerosis was evaluated by coronary angiography in 22 patients with acute myocardial infarction (AMI), 37 patients with unstable agina pectoris and 30 controls. RESULTS The concentrations of serum sVCAM1 were significantly higher in ACS patients than those in controls (P<0.01) and significantly higher in AMI patients than those in UAP patients. The concentrations of serum vWF were significantly higher in ACS patients than those in controls (P<0.01), but there was no significant difference between the AMI and UAP patients. There was a significant positive correlation between the concentration of serum sVCAM1 and the lesion extension of coronary artery (r=0.450 P<0.01). CONCLUSION Serum sVCAM1 levels are correlated with the lesion extension of coronary artery and vWF is a factor in the generation and development of ACS.

参考文献/References

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急性冠脉综合征患者炎症标志物水平及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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