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Title:: Effects of L-Carnitine on hypercholesterolemia in patients with coronary heart disease

作者:: 成静; 盛净; 杜勤; 蔡文玮; 上海交通大学附属第九人民医院老年科，上海 200011

Author(s):: CHENG Jing; SHENG Jing; DU Qin; CAI Wen-wei; Department of Geriatrics,Shanghai 9th People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200011,China

关键词:: 冠状动脉疾病; 左卡尼汀; 高脂血症

Keywords:: coronary disease; L-Carnitine; hypercholesterolemia

分类号:: R541.6

DOI:: -

文献标识码:: A

摘要:: 目的观察左卡尼汀在冠心病高胆固醇血症患者中的临床疗效及其安全性。方法选择冠心病伴高胆固醇的患者40例，予左卡尼汀3.0 g/d，连续15 d静脉滴注，以后改用左卡尼汀口服液1.0 g，3次/d，连续15 d 。治疗前后比较每周心绞痛发作次数以及硝酸甘油片用量，心电图、超声心动图、血脂、肝肾功能生化指标变化。结果左卡尼汀治疗2~4周后患者心绞痛发生次数及硝酸甘油片用量显著减少，ST段缺血型下移之和∑ST减小，心脏指数和左室射血分数显著改善；左卡尼汀治疗后2周总胆固醇和甘油三脂降低，高密度脂蛋白胆固醇升高。结论左卡尼汀可以缓解冠心病患者的临床症状，减轻心肌缺血，改善心功能，并且可以调节血脂水平，不良反应少。

Abstract:: AIM To observe the therapeutic effects of LCarnitine on hypercholesterolemia in patients with coronary heart disease. METHODS Forty patients with hypercholesterolemia diagnosed as coronary heart disease (CHD) were treated by L-Carnitine for 30 days. Angina pectoris attack frequency, weekly nitroglycerin consumption, electrocardiogram, ultrasonography, serium lipids and hepatic-renal function were measured before and after the therapy. RESULTS ①After L-Carnitine treatment, angina pectoris attack frequency and weekly nitroglycerin consumption decreased obviously and ∑ST depression improved. The cardiac index (CI) and left heart ejecting function (EF) increased after the 2-4 weeks treatment. ②The total serum cholesterol and triglyceride decreased and HDLCholesterol level increased after L-Carnitine treatment. CONCLUSION L-Carnitine has obvious anti-ischemic effect on CHD patients and a good protective effect on myocardium. It can also regulate the level of serum lipids with few side effects.

参考文献/References

［1］殷仁富，陈金明. 心脏能量学：代谢与治疗［M］. 上海：第二军医大学出版社,2002.263-275.

［2］中华心血管病杂志编辑委员会血脂异常防治对策组．血脂异常防治建议［J］．中华心血管病杂志，1997,25(3):169-175.

［3］ Lango R, Smolenski RT, Narkiewicz M, et al. Influence of LCarnitine and its derivatives and during cardiopulmonary bypass ［J］. Cardiovasc Res, 2001, 51(1): 21-29.

［4］ Allard MF. Energy Substrate Metabolism in Cardiac Hypertrophy ［J］. Curr Hypertens Rep, 2004, 6(6): 430-435.

［5］吴奇志, 翁南星, 兰启防. 阿托伐他汀钙对原发性高胆固醇血症患者血管内皮细胞依赖性舒张功能的影响［J］. 心脏杂志, 2002, 14(6):494-496.

［6］高智耀，雷兆军，李亚军. 辛伐他汀在不稳定型心绞痛患者早期应用的疗效［J］.心脏杂志， 2004,16(2): 140-142.

［7］ Pauly DF, Pepine CJ. The role of carnitine in myocardial dysfunction ［J］. Am J Kidney Dis, 2003,41(Suppl 4): S35-S43.

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左卡尼汀对冠心病高胆固醇血症的疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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