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|本期目录/Table of Contents|

倍他乐克治疗围生期心肌病的疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第4期
页码:
460-461
栏目:
临床研究
出版日期:
2006-08-25

文章信息/Info

Title:
Clinical study of the Betaloc on peripartum cardiomyopathy
作者:
梁锦军1; 黄从新1; 杨波1; 许家俐1; 杨勇2; 田立群3; 朱刚艳1
1.武汉大学人民医院心内科，湖北 武汉 430060；2.陨阳医学院附属太和医院心内科；3.武汉市第一医院心内科
Author(s):
LIANG Jin-jun1;  HUANG Cong-xin1;  YANG Bo1;  XU Jia-li1;  YANG Yong2;  TIAN Li-qun3;  ZHU Gang-yan1
1.Department of Cardiology,Renmin Hospital of Wuhan University, Wuhan,Hubei 430060，China; 2. Department of Cardiology,Taihe Hospital of Yunyang Medical College;3 Department of Cardiology, first Hospital of Wuhan
关键词:
倍他乐克; 心肌病; 围生期; 临床疗效
Keywords:
betaloc; cardiomyopathy; peripartum; clinical efficiency
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 了解倍他乐克治疗围生期心肌病的临床效果。方法 回顾符合诊断标准的17名住院患者，按治疗方案分成两组：对照组(8例):给予地高辛0.125～0.250 mg/d， 间断使用双氢克尿噻25 mg， 1～3次/d，安体舒通20 mg, 1次/d；开搏通12.5 mg, 1～2次/d。倍他乐克组(9例)：对照组用药+倍他乐克，开始剂量6.25 mg, 1次/d, 适应后加量至12.5 mg, 1～2次/d，维持4周，根据病情酌情给予抗凝治疗；分别测量两组的左室射血分数（LVEF）并计算住院时间。结果 两组患者的年龄、治疗前LVEF无明显差异；治疗后与对照组比较，倍他乐克组LVEF明显改善，心功能改善程度和住院时间两者比较有显著差异（P<0.05）。结论 倍他乐克可明显提高LVEF，有效改善心功能，缩短住院时间，减轻患者负担，提高生活质量。
Abstract:
AIM To investigate the efficiency of Betaloc on peripartum cardiomyopathy. METHODS Seventeen patients with peripartum cardiomyopathy were randomly divided into two groups : the control group (n=8) and the Betaloc group (n=9). Patients in the control group were given Digoxin，DHCT，Antisterone，and Capotral, and those in the Betaloc group were given betaloc (from 6.25 mg Qd to 12.5 mg QdBid) in addition to the medicine given to the control group. LVEF were measured before and 4 weeks after the therapy. RESULTS LVEF in the Betaloc group was enhanced significantly than that in control group after therapy (P<0.05);and the hospitalized time could be obviously shortened compared with the control group(P<0.05). CONCLUSION Betaloc increases LVEF and improves cardiac function in patients with peripartum cardiomyopathy.

参考文献/References

［1］ Ferrero S，Colombo BM，Fenini F，et al. Peripartum Cardiomyopathy. A review［J］. Minerva Ginecol, 2003, 55(2):139-158.

［2］ Fung JW,Yu CM,Yip G,et al. Effect of beta blockade (carvedilol or metoprolol) on activation of the reninangiotensinaldosterone system and natriuretic peptides in chronic heart failure［J］. Am J Cardiol,2003,92(4):406-410.

［3］ George C. Heart failure: aetiology, diagnosis,and treatment［J］. Heart,2002,88(6):567-569.

［4］ Foody JM,Farrell MH,Krumholz HM. Betablocker therapy in heart failure:scientific review［J］. JAMA,2002,287(7):883-889.

备注/Memo

备注/Memo:
收稿日期：2004-12-07.作者简介：梁锦军,硕士生 Tel：(027)62974420 Email：ljjfly@sina.com
更新日期/Last Update: