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Title:: Comparison of global dispersion with local dispersion of ventricular repolarization measured with monophasic action potential mapping technique in swine

作者:: 梁延春¹; 韩雅玲¹; 吴国超²; 王祖禄¹; 袁世文³; 1.沈阳军区总医院心血管内科，辽宁沈阳 110016；2.解放军第187医院医务处，海南海口 571159；3.隆德大学医院心血管内科, 瑞典隆德 S-22185

Author(s):: LIANG Yan-chun¹; HAN Ya-ling¹; WU Guo-chao²; WANG Zu-lu¹; YUAN Shi-wen³; 1.Department of Cardiology, General Hospital, Shenyang Military Area Command, Shenyang, Liaoning 110016, China; 2.Department of Medicine office,187 Hospital of PLA,Haikou,hainan 571159,China; 3.Department of Cardiology, University Hospital of Lund, Lund S22185, Sweden

关键词:: 单相动作电位; 复极; 离散度

Keywords:: monophasic action potential; repolarization; dispersion

分类号:: R541.7

DOI:: -

文献标识码:: A

摘要:: 目的评价整体心室复极离散度（dispersion of ventricular repolarization，DVR）能否从心内膜几个邻近点或几个远距离点的标测来估测。方法应用CARTO标测系统，在10头猪左心室心内膜的（75±12）个位点记录单相动作电位。计算每一点复极结束时间(endofrepolarization time，EORT)和动作电位时程(monophasic action potential duration，MAPD)。关于EORT和MAPD的整体DVR与相应的局部DVR进行比较。局部DVR包括面积在 2 cm2内的邻近DVR；还包括左室最早和最晚激动点间的远距离DVR1以及左室心尖部和外基底部间的远距离DVR2。结果关于EORT和MAPD的邻近DVR［（15±4和12±4）ms］显著小于相应的整体DVR［（84±31和77±26）ms，P<0.01］。远距离DVR1［（42±19和23±14 ）ms］和远距离DVR2［（25±16和18±11）ms］显著大于邻近DVR（P<0.01），但仍显著小于整体DVR（P<0.01）。结论从心内膜几个邻近点或几个远距离点的标测不能良好地估测整体DVR。在估测整体DVR中获取整体信息很重要。

Abstract:: AIM To evaluate whether the global dispersion of ventricular repolarization (DVR) can be estimated from the measurements between a few adjacent or remote sites. METHODS Monophasic action potentials (MAPs) were recorded from (75±12) left ventricular endocardial sites in 10 pigs by using the CARTO mapping system. Endofrepolarization time (EORT) and MAP duration (MAPD) were calculated at each site and ten sets of 3dimensional repolarization maps were constructed. Global DVRs in EOR and MAPD were compared with the adjacent DVR in areas <2 cm2 and remote DVRs between 2 MAPs with the greatest activation time difference (remote DVR1) and between the apical and laterobasal left ventricle (remote DVR2). RESULTS The adjacent DVRs in EOR and MAPD were significantly smaller than the global ones ［(15±4 and 12±4) ms vs (84±31 and 77±26) ms respectively, P<0.01)］. Both the two remote DVR parameters, (42±19 and 23±14) ms for remote DVR1 and (25±16 and 18±11) ms for remote DVR2, were markedly greater than the adjacent ones (P<0.01), but still significantly smaller than the global DVR values (P<0.01). CONCLUSION Global DVR can not be satisfactorily estimated from MAP recordings from a few adjacent or remote sites. Obtaining global information is of great importance in evaluating DVR.

参考文献/References

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猪整体和局部心室复极离散度的单相动作电位标测比较(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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