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Title:: Association between Connexin 37 gene polymorphism and coronary heart disease

作者:: 谢学建¹; 郭文怡¹; 李兰荪¹; 舒青²; 姜文瑞³; 张淑珍¹; 李飞¹; 第四军医大学：1.西京医院心血管内科，陕西　西安　710032；2.基础部遗传与发育教研室，陕西西安　710032；3.唐都医院心血管内科，陕西　西安　710038

Author(s):: XIE Xue-jian¹; GUO Wen-yi¹; LI Lan-sun¹; SHU Qing²; JIANG Wen-rui³; ZHANG Shu-zhen²; LI Fei¹; 1.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi′an, Shaanxi 710032 China, 2.Department of Genetic and Departmental Biology, Fourth Military Medical University, Xi′an, Shaanxi 710032 China, 3.Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi′an, Shaanxi 710029, China

关键词:: 冠状动脉疾病; 间隙连接蛋白基因; 基因多态性; 基因频率

Keywords:: Coronary diease; Connexin 37 gene; Gene polymorphism; Gene frequency

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的探讨陕西汉族人群间隙连接蛋白37（Connexin 37，Cx37）基因多态性与冠心病的关系。方法采用聚合酶链反应和限制性片段内切酶的方法检测了150例冠心病患者(冠状动脉造影证实)及117例对照者的Cx 37基因多态性。结果冠心病患者T等位基因频率高于对照组(0.25 vs 0.21)，两组间3种基因型(TT、TC和CC)分布无显著性差异。在男性群体中，冠心病患者T等位基因频率高于对照组(0.254 vs 0.243)，3种基因型(TT、TC和CC )分布在两组男性间，无显著性差异。结论汉族人群中存在Cx37基因多态性，其多态性与冠心病发病无关。

Abstract:: AIM To investigate the association between Connexin 37 (Cx37) gene polymorphism and coronary heart disease (CHD) in population of Shaanxi Han nationality. METHODS Samples of peripheral blood white cells were extracted from 150 patients with CHD, aged 61±10, and from 117 controls without cardiovascular diseases, aged 60±8. The subjects under study were all of Chinese Han nationality. The Cx 37 polymorphism was determined by polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP). RESULTS The frequency of the Cx37 gene T allele (0.25 vs 0.21) was higher in the CHD group than that in the controls, but the frequencies of three genotypes were not significantly different in both groups . In the male group, the frequency of the Cx37 gene T allele (0.254 vs 0.243) was higher in the CHD group than that in the controls, but the frequencies of three genotypes were not significantly different in both groups . CONCLUSION The polymorphism of Cx37 gene is present in population of Shaanxi Han nationality and there is no association between the polymorphism of Cx37 gene and CHD.

参考文献/References

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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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