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青壮年高血压病患者血管紧张素Ⅱ 1型受体基因多态性分析(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第6期
页码:
647-649
栏目:
临床研究
出版日期:
2006-12-25

文章信息/Info

Title:
Angiotensin II type 1 receptor gene polymorphism in young hypertension patients
作者:
彭澍1; 彭健2; 龚五星1; 方明1; 赵艳1
1.暨南大学医学院附属第三医院 珠海市人民医院，广东 珠海，519000；2.中山大学附属第五医院心内科
Author(s):
PENG Shu1;  PENG Jian2;  GONG Wu-xing1;  FANG Ming1;  ZHAO Yan1
1.Department of Cardiology, Third Hospital of Jinan University, Zhuhai，Guangdong 519000; 2.Department of Cardiology, Fifth Hospital of Zhongshan University
关键词:
高血压; 血管紧张素Ⅱ1型受体; 基因; 多态性
Keywords:
hypertention;  angiotensin II type 1 receptor;  gene; polymorphism
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨青壮年高血压病与血管紧张素Ⅱ 1型受体（AT1R）基因A1166/C多态性的相关性。方法 应用多聚酶链式反应-限制性酶切法(PCR-RFLP)检测68例青壮年高血压病患者和84例健康对照者的AT1R基因1166位点基因型，并记录病程及基本临床指标和左室质量指数（LVMI）；多元回归法分析各临床因素与LVMI的相关性。结果 病例组AT1R基因AC/CC基因型频率高于对照组（0.22∶0.11，P<0.05），1166 C等位基因频率显著高于对照组（0.12∶0.06，P<0.01）。结论 AT1R基因1166位点AC/CC基因型及C等位基因与青壮年高血压病发病有关。
Abstract:
AIM To investigate the relationships between hypertension patients and polymorphism of Angiotensin II type 1 receptor (AT1R) gene. METHODS Polymerase chain reaction combined with restriction enzyme digestion was used to determine the polymorphism of the 1166 site of AT1R gene in 68 young hypertension patients and 84 controls. Normal indexes were measured by routine method. Left ventricular mass index and course were detected in the hypertension patients. Frequencies of AC/CC genotypes and 1166C allele of AT1R gene were compared between young hypertension patients and control. Multiple linear regression was applied to analyze the linear relation between the clinical data and LVMI. RESULTS The frequencies of AC/CC genotypes and 1166 C allele of AT1R gene in young hypertension patients were higher than those of control (AC/CC genotypes 0.22∶0.11，P<0.05; C allele 0.12∶0.06，P<0.01). CONCLUSION 1166AC/CC genotypes and 1166C allele are associated with hypertension in young people.

参考文献/References

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［2］ Chistiakov DA, Kobalova ZHD, Tereshchenko SN, et al. Polymorphism of vascular angiotensin II receptor gene and cardiovascular disorders［J］. Ter Arkh, 2000, 72(4): 27-30.

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［6］ 李南方，李涛，周玲, 等. 血管紧张素II 1型受体基因多态性与新疆哈萨克族原发性高血压的相关研究［J］. 新疆医科大学学报,2005，28（1）：1-4.

［7］ 钟亚，哈黛文. 老年高血压病合并冠心病、脑梗塞患者AT1 R基因多态性研究［J］. 中国老年学杂志,2002，22（1）：6-8.

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备注/Memo

备注/Memo:
收稿日期：2006-02-10.基金项目：广东医学科技研究基金资助项目（No.A2000632） 作者简介：彭澍，主治医师，硕士 Tel：（0756）2162004 Email：zhpeng_shu@163.com
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