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|本期目录/Table of Contents|

血尿酸和血脂代谢紊乱对冠状动脉病变的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第6期
页码:
659-660，663
栏目:
临床研究
出版日期:
2006-12-25

文章信息/Info

Title:
Relationship between level of plasma lipids, uric acid and coronary artery affection
作者:
张铭; 周胜华; 方臻飞;  成威; 吴旭斌
中南大学湘雅二院心内科，湖南 长沙 410011
Author(s):
ZHANG Ming;  ZHOU Sheng-hua;  FANG Zhen-fei;  CHENG Wei;  WU Xu-bin
Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha,Hunan 410011, China
关键词:
血尿酸; 血脂代谢紊乱; 冠状动脉粥样病变
Keywords:
uric acid ; coronary artery affection ; plasma lipids metabolic disorder
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究高尿酸血症及血脂代谢紊乱对冠状动脉粥样硬化病变的影响。方法 收集所有行冠状动脉造影检查的患者327例，按检查结果分为正常对照组113例，单支病变组70例，双支病变组72例、多支病变组72例。检测所有患者血清中的血尿酸，脂蛋白（α)［Lp（α)］,总胆固醇（TG），甘油三酯（TC）， 低密度脂蛋白（LDL），高密度脂蛋白（HDL），载脂蛋白（B）（apoB） 的水平，进行统计学分析。结果 血尿酸水平在以上各组间无统计学意义上差异，而Lp（α)，TG，TC，LDL高于正常对照组，多元相关回归分析显示：冠脉病变计分和血尿酸及TC无相关关系，LDL，HDL，apoB，TG，Lp（α)与冠心病显著相关，而TC与冠心病无独立相关。结论 尿酸与冠状动脉病变无明显相关，而血脂及糖代谢紊乱与冠状动脉粥样病变显著相关。
Abstract:
AIM To study the effect of uric acid and plasma lipids on coronary artery affection. METHODS Three hundred and twentyseven cases of patients were examined by coronary angiography and by the results of which they were divided into four groups by degree of coronary artery affection: normal control group （n=113）, single vessel lesion group （n=70）, double vessel lesion group （n=72） and multivessel lesion group（n=72）. Lp（α), uric acid and plasma lipids were measured by usual procedures and the results were statistically analyzed. RESULTS There was no association between the uric acid level and the extent and the severity of coronary artery. The levels of UA, TG, TC, Lp（α), LDLC and apoB were different among the groups, especially between normal control group and multivessel lesion group. CONCLUSION Uric acid level may have no effect on the coronary artery affection. The extent of coronary artery lesion is mainly related to plasma lipids metabolic disorder.

参考文献/References

［1］ Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease［J］. Ann Intern Med，1951，34(6):1421-1431.

［2］ Bickel C, Rupprecht HJ, Blankenberg S, et al. Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease［J］. Am J Cardiol，2002，89(1):12-17.

［3］ Moriarity JT, Folsom AR, Iribarren C, et al. Serum uric acid and risk of coronary heart disease: Atherosclerosis risk in communities (ARIC) study［J］. Ann Epidemiol，2000,10(3):136-143.

［4］ 何小俊,张永珍,柴红. 血清尿酸水平与心血管疾病的相关性分析［J］. 临床心血管病杂志，2003，19（9）：555-556.

［5］ 陆丕能，胡大一，陆鋆，等. 冠心病与血尿酸的关系［J］. 中华内科杂志，2002 ，41(8)：526-529.

备注/Memo

备注/Memo:
收稿日期：2005-10-24.作者简介：：张铭，博士生 Email：mingzhang2003@yahoo.com.cn
更新日期/Last Update: