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Title:: Association between pregnancyassociated plasma proteinA and hypertension

作者:: 王凌燕; 蔡高军; 张文伟; 孟冬梅; 王文志; 吉林大学中日联谊医院心内科，吉林长春 130031

Author(s):: WANG Lingyan; CAI Gaojun; ZHANG Wenwei; MENG Dongmei; WANG Wenzhi; Department of Cardiology,ChinaJapan Union Hospital of Jilin University,Changchun 130031,Jilin,Chin

关键词:: 妊娠相关血浆蛋白A; 白细胞介素10; 高血压

Keywords:: pregnancy associated plasma proteinA; interleukin10; hypertension.

分类号:: R544.1

DOI:: -

文献标识码:: A

摘要:: 目的通过检测外周血妊娠相关血浆蛋白A（pregnancyassociated plasma proteinA，PAPPA）的浓度，探讨PAPPA与血压之间的相关性。方法分别采用双抗体夹心酶联免疫吸附实验，双抗体放射免疫法， ABCHRP方法测定70名高血压患者及56名正常对照者血清PAPPA、IL6、IL10的浓度。结果 ①高血压病组PAPPA、IL6、IL10的浓度较对照组显著增高（P<0.05），且随血压等级的增高其浓度也增高；②PAPPA与IL6、IL10之间存在显著正相关。结论高血压患者PAPPA、IL6、IL10水平比血压正常者高，说明炎症反应可能参与高血压的发生和发展。

Abstract:: AIM To explore the relationship between PAPPA and hypertension by measuring the circulating serum PAPPA. METHODS Serum PAPPA, IL6 and IL10 were measured in 70 patients with hypertension and 56 controls with enzymatically amplified “twostep” sandwichtype immunoassay, double antibody radioimmunoassay and ABCHRP. RESULTS ①The serum levels of pappA, IL6 and IL10 were significant higher in patients with hypertension than those of the controls ( P<0.05) and elevated with the level of pressure. ②There was a significant association between PAPPA, IL6 and IL10. CONCLUSION Inflammatory cytokines ( PAPPA, IL6 and IL10) in patients with hypertension are higher, indicating that the inflammation is probably involved in the occurrence and development of hypertension.

参考文献/References

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妊娠相关血浆蛋白A与高血压病的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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