我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

氯吡格雷抵抗研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第1期
页码:
96-98
栏目:
综述
出版日期:
2007-01-01

文章信息/Info

Title:
-
作者:
白艳艳 综述王长谦 审校
上海第二医科大学附属仁济医院心内科,上海 200001
Author(s):
-
关键词:
冠状动脉疾病氯吡格雷氯吡格雷抵抗
Keywords:
-
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
氯吡格雷广泛用于急性冠脉综合征和经皮冠状动脉介入术的患者,可以减少心血管事件的发生,降低支架内亚急性血栓形成的发生率。但是临床上服用氯吡格雷的患者表现出各自不同的反应性,部分患者反应差甚至无反应,称之为氯吡格雷抵抗。本文就氯吡咯雷抵抗的定义、检测方法、机制及临床意义作一综述。
Abstract:
-

参考文献/References

[1]Clarke TA ,Waskell LA.The Metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin [J].Drug Metab Dispos,2003,31(1): 53-59.

[2]Quinn MJ, Bhatt DL, Zidar F,et al. Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention[J].Am J Cardiol,2004,93(6):679-684

[3]Nguyen TA, Diodati JG, Pharand C.Resistance to clopidogrel: A review of the evidence [J]. J Am Coll Cardiol,2005,45(8):1157-1164

[4]Xiao Z,Therous P. Clopidogrel inhibits plateletleukocyte interactions and thrombin receptor agonist peptideinduced platelet activation in patients with an acute coronary syndrome [J] . J Am Coll Cardiol,2004,43(11):1982-1988

[5]Muller I, Besta F, Schulz C,et al. Prevalence of clopidogrel nonresponders among patients with stable angina pectoris scheduled for elective coronary stent placement [J]. Thrombo Haemost,2003,89(5):783-787

[6]Geiger J,Teichmann L,Grossmann R,et al. Monitoring of clopidogrel action: comparison of methods [J]. Clin Chem,2005,51(6):957-965.

[7]朱梅,贾庆良.氯吡格雷对不稳定型心绞痛患者血小板功能的影响 [J].心脏杂志,2003,15(5):425-427.

[8]Lau WC, Waskell LA, Watkins PB, et al.Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug–drug interaction [J].Circulation,2003,107(1): 32-37.

[9]Fontana P,Dupont A, Gandrille S,et al .Adenosine diphosphate induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects [J].Circulation, 2003,108(8): 989- 995.

[10]Lau WC, Gurbel PA,Watkins PB, et al. Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of Clopidogrel resistance [J].Circulation, 2004, 109(2): 166- 171.

[11] Lepantalo A, Virtanen KS, Heikkila J, et al.Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions[J].Eur. Heart J,2004, 25(6): 476-483.

[12]Barragan P,Bouvier JL,Roquebert PO, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilatorstimulated phosphoprotein phosphorylation [J].Catheter Cardiovasc Interv ,2003,59(3):295-302.

[13]Gurbel PA, Bliden KP, Hiatt BL, et al. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity [J].Circulation, 2003,107(23): 2908 - 2913.

[14]Matetzky S, Shenkman B, Guetta V,et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction [J]. Circulation,2004,109(25): 3171–3175。

备注/Memo

备注/Memo:
收稿日期:2005-08-12.通讯作者:王长谦,主任医师,主要从事冠状动脉粥样硬化及冠心病防治研究Email:wcqian@hotmail.com 作者简介:白艳艳,硕士生Email:baiyanyan1980@yahoo.com.cn
更新日期/Last Update: