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缺血期急性高血糖加重大鼠心肌缺血/再灌注损伤(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第2期
页码:
129-131/142
栏目:
基础研究
出版日期:
2007-04-01

文章信息/Info

Title:
Hyperglycemia during ischemia aggravates reperfusionmediated myocardial injury in rats
作者:
苏慧1; 孙新2; 黄晨1; 王晓明1; 张海锋3; 张昆如3; 高峰3
第四军医大学：1.西京医院老年病二科,2.西京医院儿科,3.基础部生理学教研室，陕西 西安 710032
Author(s):
SU Hui1;  SUN Xin2;  HUANG Chen1;  WANG Xiaoming1;  ZHANG Haifeng3;  ZHANG Kunru3;  GAO Feng3
1.Second Department of Geriatrics, 2.Department of Pediatrics, Xijing Hospital, 3.Department of Physiology, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
关键词:
高血糖; 急性; 心肌缺血/再灌注损伤
Keywords:
hyperglycemia; acute;  myocardial ischemia/reperfusion injury
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨急性高血糖对大鼠心肌缺血/再灌注损伤（RMMI)缺血期和再灌注期的影响，并分析不同时期的高血糖与心肌损伤之间的关系。方法 制备急性大鼠RMMI模型（缺血30 min，再灌注6 h），静脉输注高浓度的葡萄糖液，造成急性高血糖动物模型。将SD大鼠随机分为4组：假手术组（SHAM），生理盐水对照组（CON），缺血期高糖组（HGI）和再灌注期高糖组（HGR）。术中监测血糖水平，再灌注结束后检测心肌酶谱（CK，LDH）水平和心肌梗死(MI)面积。结果 静脉输注高糖后大鼠血糖水平迅速而显著升高，造成缺血期和再灌注期急性高血糖。与CON组相比较，HGI组心肌酶谱水平显著升高，MI面积显著扩大 ［(46±9)％ vs (38±6)%, P<0.05］；而HGR组的心肌酶谱水平和MI面积与CON组相比无显著差异［(39±6)％ vs (38±6)%］。结论 缺血期急性高血糖可加重大鼠RMMI。
Abstract:
AIM To study the effects of hyperglycemia on different periods of reperfusion mediated myocardial injury(RMMI) in rats. METHODS Rats, subjected to 30 minutes of myocardial ischemia and 6 hours of reperfusion, randomly received one of the following treatments: SHAM；SON (saline throughout ischemia and reperfusion period）; HGI （administration of 50% glucose by intravenous infusion during ischemia and saline during reperfusion）; or HGR（saline during ischemia and 50% glucose during reperfusion）. Blood glucose levels were monitored throughout the experiments. Myocardial infarction(MI) size and serum myocardial enzymogram of rats were determined after the experiments. RESULTS Acute hyperglycemia during ischemia and reperfusion was successfully established after administration of high glucose intravenously. Hyperglycemia during ischemia rather than reperfusion significantly enlarged MI size and increased serum myocardial enzymogram following myocardial ischemia/reperfusion. CONCLUSION Hyperglycemia during ischemia rather than reperfusion significantly exacerbates RMMI, which can be used as a predictor of MI size and prognosis after myocardial ischemia and reperfusion.

参考文献/References

［1］Timmer JR, van der Horst IC, Ottervanger JP, et al. Prognostic value of admission glucose in nondiabetic patients with myocardial infarction［J］. Am Heart J,2004, 148(3):399-404.

［2］Ishihara M, Kojima S, Sakamoto T, et al. Acute hyperglycemia is associated with adverse outcome after acute myocardial infarction in the coronary intervention era［J］. Am Heart J,2005,150(4):814-820.

［3］Zhao ZQ,Zang YM. Alternative cardioprotective strategy during reperfnsion:postconditioning vs preconditioning［J］. 心脏杂志,2006,18(1):1-13.

［4］Gao F, Yue TL, Shi DW, et al. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation［J］. Cardiovasc Res,2002,53(2):414-422.

［5］Kersten JR, Schmeling TJ, Orth KG, et al. Acute hyperglycemia abolishes ischemic preconditioning in vivo［J］. Am J Physiol,1998,275(2 Pt 2):H721-H725.

［6］Devos P, Chiolero R, Van den Berghe G, et al. Glucose, insulin and myocardial ischaemia［J］. Curr Opin Clin Nutr Metab Care,2006, 9(2):131-139.

［7］Cai L, Li W, Wang G, et al. Hyperglycemiainduced apoptosis in mouse myocardium: mitochondrial cytochrome Cmediated caspase3 activation pathway［J］. Diabetes, 2002,51(6):1938-1948.

备注/Memo

备注/Memo:
收稿日期：2006-11-22.通讯作者：高峰，教授,主要从事缺血心肌保护研究Email：fgao@fmmu.edu.cn作者简介：苏慧，主治医师，硕士Email：huisu5016@yahoo.com.cn
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