我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

氯沙坦对高血压病患者血管内皮功能的影响及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第2期
页码:
182-184/188
栏目:
临床研究
出版日期:
2007-04-01

文章信息/Info

Title:
Effects of Losartan on vascular endothelial function in patients with essential hypertension and its clinical significance
作者:
邢绣荣; 华琦; 刘荣坤
首都医科大学宣武医院心内科，北京 100053
Author(s):
XING Xiurong;  HUA Qi;  LIU Rongkun
Department of Cardiovasology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
关键词:
高血压; 内皮功能; 氯沙坦
Keywords:
hypertension;  endothelial function;  losartan
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨氯沙坦对高血压病患者血管内皮功能的影响及其临床意义。 方法 采用血浆内皮素(ET)， 一氧化氮(NO)，血小板α颗粒膜蛋白(GMP140)和血管性假血友病因子(vWF)水平作为内皮功能指标，观察45例高血压病患者氯沙坦治疗4周前后血管内皮功能的改变。结果 高血压组治疗前血浆ET、vWF和GMP140均显著高于正常对照组，NO/ET较正常对照显著降低(P<0.05,P<0.01)。治疗4周，高血压组的血浆ET、vWF、GMP140较前显著降低(P<0.05,P<0.01 )。血浆NO及NO/ET较前显著升高，并且NO显著高于正常对照组(P<0.05,P<0.01)。ET与血总胆固醇(TC)、SBP正相关，NO和NO/ET与空腹血糖、SBP和三酰甘油显著负相关，NO/ET还与HDL正相关，vWF、GMP140与HDL负相关，GMP140与TC正相关(P<0.05,P<0.01)。结论 高血压患者存在血管内皮功能减退，内皮功能与收缩压、血糖、血脂相关联。氯沙坦能够改善高血压患者的血管内皮功能。
Abstract:
AIM To investigate the changes of vascular endothelial function in patients with essential hypertension and effects of Losartan on the patients. METHODS The plasma levels of endothelin (ET), nitric oxide (NO), von Willebrand Factor (vWF), and plate αgranule membrane protein (GMP140) were measured as the indexes of endothelial function. Fortyfive patients with essential hypertension were treated with Losartan for 4 weeks and the changes of vascular endothelial function were investigated. RESULTS The plasma ET, vWF and GMP140 in hypertensive patients before treatment were significantly higher than those in normal control and NO/ET decreased in hypertensive group (P<0.05,P<0.01). After 4 weeks' treatment, the plasma ET, vWF and GMP140 in hypertensive group were decreased markedly (P<0.05,P<0.01). The plasma NO and NO/ET were increased and NO was higher than that in normal control (P<0.05,P<0.01). ET was positive correlated to blood total cholesterol (TC) and systolic blood pressure (SBP). NO and NO/ET were negatively related to fasting blood sugar, SBP and triglyceride, while NO/ET was positive correlated to high density lipoprotein (HDL). GMP140 and vWF were negative correlated to HDL but GMP140 was positively related to TC (P<0.05,P<0.01). CONCLUSION Endothelial functions are damaged in patients with essential hypertension. The indexes of endothelial function are related to the systolic blood pressure, blood glucose and lipid. Losartan can improve the vascular endothelial functions in patients with essential hypertension.

参考文献/References

［1］ Neutel JM. Beyond the sphygmomanometric numbers: hypertension as a syndrome ［J］. Am J Hypertens, 2001, 14 (8 Pt 2):250S-257S.

［2］ 邢绣荣, 华琦. 氯沙坦对高血压患者24h动态血压的影响［J］. 首都医科大学学报, 2001, 22(3), 222-225.

［3］ Virdis A, Ghiadoni L, Sudano I, et al. Endothelial function in hypertension: role of gender ［J］. J Hypertens Suppl, 2002, 20 (2): S11-S16.

［4］ Hlubocka Z, Umnerova V, Heller S, et al. Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction?［J］.Vnitr Lek, 2002, 48 (8): 718-723.

［5］ McEwan PE, Sherry L, Kenyon CJ, et al. Regulation of the myocardial endothelin system by angiotensinII and Losartan ［J］. J Cardiovasc Pharmacol, 2000, 36 (5 Suppl 1): S144-S147.

［6］ Nadar SK, Al Yemeni E, Blann AD, et al. Thrombomodulin, von Willebrand factor and Eselectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension ［J］. Thromb Res, 2004, 113 (2):123-128.

［7］朱梅, 贾国良. 氯吡格雷对不稳定型心绞痛患者血小板功能的影响［J］. 心脏杂志, 2003, 15 (5): 425-427.

［8］ Galatius S, Wroblewski H, Sorensen VB, et al. Endothelin and von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy: different stimuli for release before and after heart transplantation?［J］. Am Heart J, 1999, 137 (3): 549-554.

［9］ Gewaltig MT, Kojda G. Vasoprotection by nitric oxide: mechanisms and therapeutic potential ［J］. Cardiovasc Res, 2002, 55 (2): 250-260.

［10］Nadar S, Lip GY. The prothrombotic state in hypertension and the effects of antihypertensive treatment ［J］. Curr Pharm Des, 2003, 9 (21):1715-1732.

［11］Schiffrin EL, Park JB, Intengan HD, et al. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist Losartan ［J］. Circulation, 2000, 101 (14): 1653-1659.

［12］李爱国, 任绪义, 尤乃祯, 等. 原发性高血压患者氯沙坦治疗前后血浆内皮素及心房钠尿肽的变化［J］. 心脏杂志, 2001, 13 (5): 418.

［13］Chabielska E, Matys T, Kucharewicz I, et al. The involvement of AT2receptor in the antithrombotic effect of losartan in renal hypertensive rats ［J］. J Renin Angiotensin Aldosterone Syst, 2000, 1 (3):263-267.

备注/Memo

备注/Memo:
收稿日期：2006-03-22.通讯作者：华琦，主任医师，教授，主要从事心血管疾病研究Email：huaqi5371@medmail.com.cn 作者简介： 邢绣荣，主治医师，博士Email：xingxr@126.com
更新日期/Last Update: