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|本期目录/Table of Contents|

单硝异山梨醇酯和硝酸甘油治疗不稳定型心绞痛效果比较(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第2期
页码:
197-199
栏目:
临床研究
出版日期:
2007-04-01

文章信息/Info

Title:
Comparison of nitroglycerin and isosorbidemononitrate in treating unstable angina pectoris
作者:
侯贺功;  赵秀梅; 王红兵; 吕秋霞
巨野县人民医院心内科,山东 巨野 274900
Author(s):
HOU Hegong;  ZHAO Xiumei; WANG Hongbing; L Qiuxia
Department of Cardiology, People’s Hospital of Juye County, Juye 274900, Shandong, China
关键词:
硝酸甘油; 单硝异山梨醇酯; 心绞痛; 不稳定型; 治疗。
Keywords:
nitroglycerin;  isosorbidemononitrate;  unstable angina pectoris;  treatment
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 比较口服单硝异山梨醇酯和静脉持续滴注硝酸甘油治疗不稳定型心绞痛（UAP）的治疗效果。方法 UAP患者200例随机分为口服单硝异山梨醇酯(ISMN)组和持续静脉滴注硝酸甘油（NTG）组，治疗48 h。NTG组起始剂量10 μg/min,最大用量80～100 μg /min；ISMN组起始剂量20 mg Q6h, 最大用量20～40 mg Q6h。比较两组患者治疗后48 h临床症状和心电图改善情况。结果 ①ISMN组和NTG组对UAP患者的临床症状和心电图改善情况无显著差异。②用药后ISMN组较NTG组难治性心绞痛发生率无显著差异（12％ 比11％）。③用药后发生低血压：ISMN组0例，NTG组6例（6％）,两组差异显著（P<0.01）。结论 口服ISMN与持续静脉滴注NTG治疗不稳定型心绞痛同样安全、有效，均可降低难治性心绞痛发生的风险，但口服ISMN方便、经济、临床易掌握。
Abstract:
AIM To investigate the treatment efficacy of uninterruptedly intravenous infusion nitroglycerin (NIG) and oral administration of isosorbidemononitrate (ISMN) in patients with unstable angina pectoris (UAP). METHODS A total of 200 inpatients with unstable angina pectoris were enrolled and were randomized either to NIG group or ISMN group. NIG was administered 10 μg/min at the initiation of treatment and the largest dosage was 80-100 μg/min and ISMN was orally taken 20 mg per6 h at the initiation of treatment and the largest dosage was 20-40 mg per6 h. The treatment of the two groups was kept for 48 hours and the efficacy in the improvement of symptoms and electrocardiogram was compared. RESULTS ①No significant difference between the NIG group and ISMN group was found in the improvement of symptoms and electrocardiogram in UAP patients. ②No significant difference was found between the ISMN group and NIG group in the occurrence of refractory angina pectoris （12％ vs 11％）. ③Significant difference was found in the occurrence of hypotension between ISMN group (0 case) and NIG group (6 cases). CONCLUSION Oral administration of ISMN and uninterruptedly intravenous infusion NTG both are effective and safe in lowering the risk of refractory angina pectoris in UAP patients, but oral administration of ISMN is more convenient and economic.

参考文献/References

［1］ Braunwald E,Antman EM,Beasley JW,et al. ACC/AHA guideline update for the management of patients with unstable angina and nonSTsegment elevation myocardial infarction-2002:summary article: a report of the American College of Cardiology/American Heart Association Task Force Guidelines (Committee on the Management of Patiens With Unstable Angina)［J］. Circulation,2002, 106(14):1893-1900.

［2］ 王士雯，钱方毅. 老年心脏病学［M］.第2版.北京：人民卫生出版社，1999:325-325.

备注/Memo

备注/Memo:
收稿日期：2006-05-24.作者简介:侯贺功，主治医师Email:hhg20008@yahoo.com.cn
更新日期/Last Update: