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U50488H对低氧性肺动脉高压大鼠体内一氧化氮、内皮素及血管紧张素II水平的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第3期
页码:
249-251/257
栏目:
基础研究
出版日期:
2007-06-01

文章信息/Info

Title:
Effects of U50488H on contents of NO, ET and Ang II in hypoxic pulmonary hypertension rats
作者:
孙新1; 2; 苏慧3; 臧益民1; 王跃民1; 毕辉1; 郭海涛1; 槐勇1; 裴建明1
第四军医大学：1. 基础部生理学教研室,2.西京医院儿科,3. 西京医院老年病二科，陕西 西安 710032
Author(s):
SUN Xin1; 2;  SU Hui3;  ZANG Yimin1;  WANG Yuemin1;  BI Hui1;  GUO Haitao1;  HUAI Yong1;  PEI Jianming1
1.Department of Physiology, School of Basic Medicine, 2.Department of Pediatrics, Xijing Hospital, 3.Second Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
关键词:
κ阿片受体激动剂; 低氧性肺动脉高压; 一氧化氮; 内皮素; 血管紧张素II
Keywords:
U50488H;  hypoxic pulmonary hypertension;  nitric oxide;  endothelin;  angiotensin II
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究κ阿片受体激动剂(U50488H)对低氧性肺动脉高压（HPH）大鼠体内一氧化氮（NO）、内皮素(ET)及血管紧张素II(Ang II)等血管活性物质水平的影响，初步探讨其防治HPH的作用机制。方法 将实验动物随机分为正常对照组、低氧2周组、低氧2周＋生理盐水组及低氧2周＋U50488H组，采用低压低氧法建立大鼠HPH动物模型。2周后收集大鼠动脉血和肺组织，检测不同标本中血管活性物质NO、ET和Ang II水平。结果 慢性低氧2周后，大鼠血清及肺组织中NO水平显著降低，而血浆及肺组织中的ET和Ang II水平则显著升高（P<0.01）。U50488H可明显升高HPH大鼠血清及肺组织NO水平，同时显著降低HPH大鼠血浆及肺组织中的ET和Ang II水平（P<0.01）。结论 U50488H可调节HPH大鼠体内的血管活性物质水平，其有可能通过刺激血液及肺组织NO的分泌，抑制ET和Ang II的产生来实现对HPH的防治作用。
Abstract:
AIM To study the effects of U50488H on the contents of NO, ET and Ang II in HPH rats and to explore the mechanisms underlying the preventive and therapeutic effects of U50488H on hypoxic pulmonary hypertension (HPH). METHODS Thirtytwo rats randomly received one of the following treatments: normoxia control, 2w hypoxia, 2w hypoxia + normal saline and 2w hypoxia+U50488H. The rats were exposed to lowpressure and lowoxygen condition in an automodulating hypobaric and hypoxic cabin (air pressure 50 kPa) to establish HPH animal model. After 2 weeks of chronic hypoxia, concentrations of NO, ET and Ang II in blood and the contents in lung tissues were detected by nitrate reductase assay or radio immunoassay. RESULTS After 2 weeks of chronic hypoxia, NO level decreased while ET and Ang II levels increased remarkably in both blood and lung tissues（P<0.01）. In 2w hypoxia + U50488H group, the concentration of NO was higher and the concentration of ET and Ang II were lower than those of 2w hypoxia group（P<0.01）. CONCLUSION U50488H significantly increases NO content and decreases ET and Ang II contents in both blood and pulmonary tissues of HPH rats. It may be one of the mechanisms underlying the preventive and therapeutic effect of U50488H on HPH.

参考文献/References

［1］ Tai KK, Jin WQ, Chan TYK, et al. Characterization of ［3H］U69593 binding sites in the rat heart by receptor binding assays ［J］. J Mol Cell Cardiol, 1991, 23(11): 1297-1302.

［2］ 毕辉,朱妙章,王跃民,等.U50488H对大鼠血压的影响及机制［J］. 医学研究生学报, 2004, 17(5): 404-407.

［3］ 孙 新,臧益民,王跃民,等. U50488H对大鼠肺动脉的舒张作用及机制［J］.心脏杂志, 2004,16(6):513-516.

［4］ Sun X, Ma S, Zang YM, et al. Vasorelaxing effect of U50488H in pulmonary artery and underlying mechanism in rats ［J］. Life Sci, 2006, 78(21):2516-2522.

［5］ Pei JM， Sun X, Guo HT, et al.U50488H depresses pulmonary pressure in the rats subjected to chronic hypoxia ［J］. J Cardiovasc Pharmacol, 2006, 47(4):594-598.

［6］ Pei JM, Chen M, Wang YM, et al. kappaopioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats ［J］. sheng Li xue Bao, 2003, 55(1): 91-95.

［7］ 陈迈, 裴建明, 李兰荪, 等. U50488H对腹主动脉的舒张作用及其机制［J］.第四军医大学学报,2001, 22(1):29-32.

备注/Memo

备注/Memo:
收稿日期：2007-01-24.基金项目: 国家自然科学基金(No. 30370580)及全军医药卫生科研基金(01MB129,06MA203)通讯作者：裴建明，教授，主要从事心脏内分泌的研究Email：Jmpei8@fmmu.edu.cn作者简介：孙新，主治医师，讲师，博士Email:sunxin6@fmmu.edu.cn
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