我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

健康体检人群Brugada心电图征发生率的初步调查和随访(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第3期
页码:
335-338
栏目:
临床研究
出版日期:
2007-06-01

文章信息/Info

Title:
Preliminary studies of prevalence and followup of electrocardiographic sign of Brugada syndrome in people under routine medical checkup
作者:
杨溶海;  孟素荣;  彭健;  陈哲明;  阮发晖;  王凡;  王蔚;  谢昌联;  冯旭光
南方医科大学附属南方医院心血管内科，广东 广州 510515
Author(s):
YANG Ronghai;  MENG Surong;  PENG Jian;  CHEN Zheming;  RUAN Fahui;  WANG Fan;  WANG Wei;  XIE Changlian;  FENG Xuguang
Department of Cardiovascular Diseases, Nanfang Hospital, Guangzhou 510515, Guangdong, China
关键词:
流行病学; Brugada 综合征; 室性心律失常
Keywords:
epidemiology;  Brugada syndrome;  Ventricular arrhythmia
分类号:
R442.8
DOI:
-
文献标识码:
A
摘要:
目的 通过调查健康体检者Brugada心电图征的发生率，获得中国人Brugada心电图征的流行病学资料，并通过随访，了解Brugada心电图征人群的短期预后。 方法 收集了2003年6月至2005年1月我们医院查体中心健康体检人群45 152份心电图资料，按照2002 年欧洲心脏学会( ECS)专家共识报告提出的标准［1］筛选出Brugada心电图征。随访分两组:A组确诊为Brugada综合征患者(9人),B组为无症状Brugada心电图阳性人群(73人)。结果 共82人具有Brugada 心电图征,占总数的1.82‰,其中男性73人,女性9人。Ⅰ型心电图征的18人，Ⅱ型38人，Ⅲ型26人, 其中符合Brugada综合征共9人。随访结果：A组（24±12）个月的随访期内室性心动过速发生率为2/9, B组（27±11）个月的随访期内室性心动过速发生率为3%(2/73)，两组相比具有显著性差异（P<0.05）,两组人群均无人猝死。结论Brugada 心电图征在广东省健康成年人发生率为1.82‰,男女比8∶1。在随访中发现, Brugada综合征患者要比无症状Brugada 心电图征人群预后差, 容易发生致命性的室性心律失常。
Abstract:
AIM To evaluate the prevalence of electrocardiographic sign of Brugada syndrome in people under routine medical checkup and to study the shortterm prognosis of people with Brugadatype Electrocadiogram. METHODS We analyzed 45152 ECGs collected between June, 2003 and January, 2006 from the medical examination center of our hospital. The criteria recommended by European Society of Cardiology were used to identify subjects with electrocardiographic sign of Brugada syndrome. For followup, subjects with Brugadatype electrocardiogram were divided into two groups: 9 diagnosed as Brugada syndrome were in group A and 73 in group B were asymptomatic. RESULTS Brugada ECG pattern was seen in 1.82 (82 of 45152) of healthy Cantonese adults, including 73 males and 9 females. Among them, 18 ECGs (0.40 ) were classified as Brugada ECG pattern typeⅠ, 38 (0.84‰) as typeⅡ and 26 (0.58‰) as type Ⅲ. After a mean followup period of 24 months (standard deviation, 12), new fatal arrhythmic events occurred in 22% (2/9) of the patients in group A and 3% (2/73) of patients in group B. No sudden death occurred in group A and group B. CONCLUSION The incidence of the people with Brugadatype electrocadiogram in healthy Cantonese is 1.82 and the gender ratio of male to female was 8:1. Patients with Brugada syndrome have a poorer prognosis and higher likelihood of arrhythmia recurrence compared with those without Brugada syndrome.

参考文献/References

［1］Wilde AA , Antzelevitch C , Borggrefe M , et al. Proposed diagnostic criteria for the Brugada syndrome : consensus report［J］. Circulation , 2002,106(19): 2514-2519.

［2］Brugada P,Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report ［J］.J Am Coll Cardiol, 1992,20（6):1391-1396.

［3］Antzelevich C. The Brugada syndrome: diagnostic criteria and cellular mechanisms ［J］.Eur Heart J,2001,22 (5): 356-363.

［4］Brugada J,Brugada R,Brugada P. Right bundlebranch block and ST segment elevation in leads V1 though V3: A maker for sudden death in patiens without Demonstrable structural heart disease［J］. Circulation， 1998,97(5):457-460.

［5］Priori SG, Napolitano C,Gasparini M, et al. Clinical and genetic heterogeneity of right bundle branch block and ST segment elevation syndrome:a prospective Evalution of 52 families［J］. Circulation, 2000, 102(20): 2509-2515.

［6］Antzelevitch C, Brugada P, Borggrefe M ,et al. Brugada syndrome report of the second consensus conference［J］.Circulation, 2005,111(5):659-670.

［7］Atarashi H,Ogawa S, Harumi K,et al. ThreeYear followUp of patients With right bundle branch block and ST segment elevation in the right precordial leads ［J］. J Am Coll Cardiol,2001,37(7):1916-1920.

［8］Greer RW,Glancy DL,Prevalence of the Brugada electrocardiographic pattern at the Medical Center of Louisiana in New Orleans［J］. J La State Med Soc, 2003,155(5):242-246.

［9］Eckardt L, Probst V,Smits JP, et al. Longterm prognosis of individuals with right precordial STsegment elevation Brugada syndrome［J］.Circulation,2005,111(3):257-263.

［10］Priori SG，Napolitano C，Gasparini M，et al. Naturral history of Brugada syndrome:insights for risk stratification and management ［J］.Circulation, 2002,105(11):1342-1347.

［11］Mok NS, Priori SG,Napolitano C, et al. Clinical profile and genetic basis of Brugada syndrome in the Chinese population［J］. Hong Kong Med J,2004,10(1):32-37.

备注/Memo

备注/Memo:
收稿日期：2006-07-25.基金项目：广东省国际科技合作项目（No.2004B50301009）; 十五军队科技攻关项目（No.01MAB0）通讯作者：孟素荣，教授,主要从事心脏起搏与电生理方面研究Email:mengsr@fimmu.edu.cn 作者简介：杨溶海，硕士生Email:yrh7817@fimmu.com
更新日期/Last Update: