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超声心动图在评估犬慢性心力衰竭模型中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第5期
页码:
528-530
栏目:
基础研究
出版日期:
2007-10-01

文章信息/Info

Title:
Echocardiography in evaluating chronic heart failure model induced by rapid ventricular pacing
作者:
付治卿1刘涛2米亚非1周声安1李小鹰1
解放军总医院: 1.老年心内科,2.老年超声科,北京 100853
Author(s):
FU Zhiqing1 LIU Tao2 MI Yafei1 ZHOU Shengan1 LI Xiaoying1
1.Department of Geriatric Cardiology, 2.Department of Geriatric Ultrasound, PLA General Hospital, Beijing 100853, China
关键词:
心力衰竭慢性动物模型超声心动描记术血流动力学
Keywords:
chronic heart failure animal model echocardiography hemodynamics
分类号:
R541. 61;R540. 45
DOI:
-
文献标识码:
A
摘要:
目的 探讨超声心动图在评估犬慢性心力衰竭模型中的作用。方法 对10只比格犬进行快速右心室起搏,起搏前及起搏4周停止起搏后进行多普勒超声心动图和血流动力学检查。结果 快速右心室起搏4周后,所有犬都出现气促、四肢浮肿等情况,并有不同程度的胸、腹腔积液。超声心动图示左室EF、FS较起搏前显著降低(P<0.01),分别为(0.63±0.05) vs (0.42±0.10)和(0.33±4.50) vs (0.19±6.19);血流动力学检测示犬左室±dp/dtmax较起搏前均显著降低(P<0.01),分别为[(9846±415) vs (3330±307)mmHg/s]和[(-7925±3558) vs (-2260±113) mmHg/s]。起搏前后犬左室EF和FS值与+dp/dtmax值呈良好的正相关(P<0.01)。结论通过超声心动图和血流动力学指标的相关性分析,表明超声心动图在评价心力衰竭动物模型上是无创、便捷、重复性好的方法。
Abstract:
AIM To investigate the role of echocardiography in evaluating chronic heart failure models induced by rapid ventricular pacing. METHODS Ten beagle dogs received rapid right ventricular pacing at the rate of 230 beats per minute. Echocardiographic and hemodynamic measurement were performed before operation and four weeks after rapid pacing. The measured parameters included endsystolic/diastolic diameters of left ventricle (LVEDS, LVEDD), the left ventricular systolic and enddiastolic pressure, the maximal rate of left ventricular pressure rising and descending (±dp/dtmax). RESULTS After paced with 230 l/min for 4 weeks, all beagles present breathlessness, acral edema and seroperitoneum. Compared with baseline, EF and FS of paced beagles significantly declined(P<0.01), respectively (0.63±0.05) vs (0.42±0.10) and (0.33±4.50) vs (0.19±6.19); ±dp/dtmax also significantly decreased(P<0.01), respectively [(9846±415) vs (3330±307)mmHg/s]and [(-7925±3558) vs (-2260±113)mmHg/s] . There were good correlatio between EF/FS and +dp/dtmax (P<0.01). CONCLUSION Echocardiography is a noninvasive and convenient method in evaluating chronic heart failure models.

参考文献/References

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[3] 张健, 杜新平, 李彦华, 等. 经皮穿刺快速右室起搏方法建立老龄犬充血性心力衰竭模型,初步探寻心功能失代偿点[J].心脏杂志, 2005,17(1): 1-3,7.

[4] Cheitlin MD, Armstrong WF, Aurigemma GP, et al .ACC/AHA/ ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (ACC/AHA/ ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography) [J] . J Am Coll Cardiol, 2003, 42 (5): 954-970.

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备注/Memo

备注/Memo:
收稿日期:2006-08-18.基金项目:国家重点基础研究发展规划项目资助(No.G2000056906)通讯作者:李小鹰,教授,主要从事慢性心力衰竭研究Email: lixy @mx. cei. gov.cn作者简介:付治卿,住院医师,博士生 Email: fuzhiqing77@163.com
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