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Title:: Related factors for aspirin resistance in patients with coronary heart disease

作者:: 潘玉环¹; 李学奇²; 1.黑龙江省农恳总局医院心内科，黑龙江哈尔滨 150088；2.哈尔滨医科大学附属第四医院

Author(s):: Pan Yuhuan; Li Xueqi; Department of Cardiology， Heilongjiang General Hospital, Agriculture Bureau, Haerbin 150088, Heilongjiang, China

关键词:: 冠状动脉疾病; 阿司匹林抵抗; 血小板聚集率

Keywords:: coronary disease; aspirin resistance; platelet aggregation

分类号:: R5414

DOI:: -

文献标识码:: A

摘要:: 目的观察冠心病患者发生阿司匹林抵抗的发生率，并探讨冠心病患者出现阿司匹林抵抗现象的相关因素。方法 60例病情稳定的冠心病住院患者，每日口服拜阿司匹林100 mg，连服7 d，分别以二磷酸腺苷（ADP）和花生四烯酸（AA）为诱导剂，检测血小板聚集功能。结果阿司匹林抵抗（AR）发生率为20%；阿司匹林半敏感（ASR）者占13%。与阿司匹林敏感（AS）者相比，伴有高脂血症、糖尿病的冠心病患者AR较多（50% vs 15%，P<0.05），两组年龄、性别、吸烟和并发高血压病统计无显著性差异。结论伴有高脂血症、糖尿病的冠心病患者发生阿司匹林抵抗较多，阿司匹林抵抗与年龄、性别、吸烟和并发高血压病等因素无关。

Abstract:: AIM To observe the incidence of aspirin resistance in patients with coronary heart disease and to investigate the factors leadingto aspirin resistance. METHODS Sixty patients with stable coronary heart disease received aspirin 100 mg per day and no other antiplateletagent for 7days. Aspirin resistance was analyzed by examination of blood platelet aggregation induced by adenosine diphosphate （ADP）and arachidonic acid （AA）. RESULTS 20% of the patients were found aspirin resistance and 13% of the patients were aspirin semiresponders. Aspirin resistance was significantly correlated with hyperlipodemia, diabetes mellitus (50% vs 15%, P<0.05) compared with aspirin sensitivepatients. No correlation was found among aspirin resistance and hypertension, smoking history, age and gender. CONCLUSION The incidence of aspirin resistance is 20% in the patients with coronary heart disease. Patients with diabetes and hyperlipodemia more predispose to aspirinresistance. Aspirin resistance is not correlated with age, gender, smoking history and hypertension.

参考文献/References

［1］Gum PA, KottkeMarchant K, Welsh PA,et al. A prospective,blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease［J］ . J Am Coll Cardiol,2003,41（6）:961-965.

［2］Bomstein NM ,Karepov VG, Aronovich BD,et al. Failure of aspirin treatment after stroke ［J］. Stroke,1994,25(2):275-277.

［3］Friend M,Vucenik I, Miller M. Research pointers: Platelet responsiveness to aspirin in patients with hyperlipidaemia ［J］. BMJ,2003,326(7380):82-83.

［4］Gum PA, KottkeMarchant K, Poggio ED, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease ［J］. Am J Cardiol,2001,88（3）:230-235.

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冠心病患者阿司匹林抵抗的相关因素(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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