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|本期目录/Table of Contents|

PAPPA在急性冠脉综合征中的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第5期
页码:
617-619
栏目:
综述
出版日期:
2007-10-01

文章信息/Info

Title:
-
作者:
高翔宇 综述 严松彪 审校
首都医科大学附属北京友谊医院心内科,北京 100050
Author(s):
-
关键词:
妊娠相关血浆蛋白A急性冠脉综合征不稳定斑块
Keywords:
-
分类号:
R545.3
DOI:
-
文献标识码:
A
摘要:
妊娠相关蛋白A(PAPP-A)最初是在孕妇血浆中发现的一种大分子糖蛋白,在母体血浆中随着孕周的增加逐渐增多,并认为是产前监护胎儿核型异常及宫内生长迟缓、妊高征等高危妊娠的有效指标。最近发现,在冠心病患者中血浆PAPP-A的浓度升高,PAPP-A可作为冠心病不稳定斑块的标志物,成为急性冠脉综合征患者诊断和预后的良好指标。
Abstract:
-

参考文献/References

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[2]Stulc T, Malbohan I , Malik J, et al.Increased levels of pregnancy associated plasma proteinA in patients with hypercholesterolemia:the effect of atorvastatin treatment[J].Am Heart J,2003,146(6): E21.

[3]付华,刘亚林,刘宇.早期应用阿托伐他汀对急性冠脉综合征患者血清妊娠相关蛋白A和高敏C反应蛋白水平的影响[J].中国急救医学,2006, 26(5):334-336.

[4]Miedema MD,Conover CA,Harrington SC, et al. Pregnancy associated plasma proteinA levels are markedly elevated in patients with acute myocardial infarction and are proportionally decreased by atorvastatin treatment: A dualdose, doubleblind, randomized study[J].Poster Presentations,2006, 26(5):e-72.

[5]Aso Y, Okumura K, Wakabayashi S, et al. Elevated pregnancyassociated plasma proteinA in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toebrachial index[J].J Clin Endocrinol Metab, 2004, 89(11):5713-5717.

[6] Kalousova M, Fialova L, Skrha J, et al. Oxidative stress, inflammation and autoimmune reaction in type 1 and type 2 diabetes mellitus[J].Prague Med Rep,2004,105(1):21-28.

[7]Lund J, Qin Q P, Ilva T,et al. Circulating pregnancyassociated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation[J].Circulation. 2003, 108(16): 1924-1926.

[8]DominguezRodriguez A, AbreuGonzalez P, GarciaGonzalez M, et al. Circulating pregnancyassociated plasma protein A is not an early marker of acute myocardial infarction[J].Clin Biochem,2005,38(2): 180-182.

[9]Heeschen C, Dimmeler S, Hamm C W,et al. Pregnancyassociated plasma proteinA levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis[J].J Am Coll Cardiol. 2005,45(2): 229-237.

[10]Lund J, Qin QP, Ilva T,et al. Pregnancyassociated plasma protein A: a biomarker in acute STelevation myocardial infarction (STEMI)[J].Ann Med, 2006,38(3):221-228.

[11]Laterza O F, Cameron S J, Chappell D,et al. Evaluation of pregnancy associated plasma protein A as a prognostic indicator in acute coronary syndrome patients[J].Clin Chim Acta, 2004,348(12):163-169.

备注/Memo

备注/Memo:
收稿日期:2007-03-05.通讯作者:严松彪,副教授,硕士,从事冠心病、心力衰竭诊治研究Email:mhua2005@163.com 作者简介:高翔宇,硕士生Email:xiangyugao@126.com
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