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|本期目录/Table of Contents|

冠状动脉旁路移植术后S100蛋白与TNF-α和IL-8的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第6期
页码:
713-715
栏目:
临床研究
出版日期:
2007-12-20

文章信息/Info

Title:
Correlation of S100 protein with TNF-α and IL-8 after CABG
作者:
贺涛1; 高长青2; 易定华1; 董兵2; 吴扬2
1.第四军医大学西京医院心血管外科，陕西 西安710032;2.解放军总医院心外科，北京 100853
Author(s):
HE Tao1;  GAO Chang-qing2; YI Ding-hua1;  DONG Bing2;  WU Yang2
1.Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi′an, 710032, China; 2.Department of Cardiovascular Surgery, PLA General Hospital, Beijing 100853, China
关键词:
S100蛋白; 全身炎症反应综合征; 冠状动脉旁路移植术
Keywords:
S100 protein;  systemic inflammatory response syndrome;  coronery artery bypass grafting
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
目的 通过检测S100蛋白与肿瘤坏死因子-α（TNF-α）和白细胞介素-8（IL-8）的关系，探求冠状动脉旁路移植术（CABG）与全身炎症反应综合征（SIRS）的关系。方法 从术前水平到术后24 h共6个时间点经颈内静脉采集40例患者血标本，测定血浆S100蛋白、TNF-α、IL-8浓度，并对患者术后精神神经系统进行系统检查，评价患者围术期神经系统状况。结果 所有患者术后均无死亡及明显脑损伤。再灌注后5 min时S100蛋白浓度与TNF-α和IL-8相关关系分别是：r=0.83, P<0.01; r=0.76, P<0.05。结论 S100蛋白浓度与TNF-α和IL-8浓度呈正相关，显示血浆S100蛋白浓度的早期升高可能与全身炎症反应和再灌注损伤有关。
Abstract:
AIM To observe the relationship of cerebral injury and systemic inflammatory response syndrome (SIRS) by investigating the relationship between S100 protein and TNF-α and IL-8. METHODS S100, a protein specific for cerebral tissue, was used as a marker for cerebral impairment and 40 Patients who had CABG from October in 2002 to January in 2003 were studied. The blood samples were taken from internal jugular vein at 6 time points from 24 hours preoperation to 24 hours after the cardiac surgery. S100 levels and TNF-αand IL-8 of both groups were measured. We also evaluated perioperational state of the nervous system by examining the patients′ neuropsychological system. RESULTS There were no deaths or major neurologic complications in all the patients. S100 levels at 5 min after reperfusion had significant correlation with TNF-α and IL-8 (r=0.83, P<0.01; r=0.76, P<0.05). CONCLUSION The positive correlation of S100 levels with TNF-α and IL-8 suggests that SIRS due to CABG may play an important role in the sharp rise of S100 concentration.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-11-04.基金项目：中国人民解放军后勤部临床高新技术重大项目部分内容(No.2002卫医学第18) 作者简介：贺涛，住院医师，博士生 Email：hetao4905@sina.com
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