我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

奥美拉唑对家兔心房电重构的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第1期
页码:
34-36
栏目:
基础研究
出版日期:
2008-01-20

文章信息/Info

Title:
Effect of Omeprazole on tachycardiainduced electrical remodeling of rabbit atria
作者:
程晋芳; 王玉堂; 单兆亮; 时向民; 刘建国; 郭红阳;  苑洪涛
解放军总医院心内科，北京 100853
Author(s):
CHENG Jinfang;  WANG Yutang;  SHAN Zhaoliang;  SHI Xiangmin;  LIU Jianguo;  GUO Hongyang;  YUAN Hongtao
Department of Cardiology, PLA General Hospital, Beijing 100853, China
关键词:
心房颤动; 质子泵抑制剂; 奥美拉唑; 家兔
Keywords:
atrial fibrillation;  proton pump inhibitor;  Omeprazole;  rabbit
分类号:
R541.75
DOI:
-
文献标识码:
A
摘要:
目的 探讨质子泵抑制剂奥美拉唑对心房快速起搏所致家兔心房电重构的影响。方法 24只家兔随机分为4组：生理盐水组、奥美拉唑组、生理盐水＋起搏组和奥美拉唑＋起搏组。其中生理盐水＋起搏组和奥美拉唑+起搏组，分别在静脉注射生理盐水和奥美拉唑后，以最快的心房 1∶1 起搏频率(500～600次/min)行快速心房起搏3 h，分别于起搏前、起搏后0.5、1、1.5、2、2.5和3 h 测定基础刺激周长分别为200 ms和150 ms时右心房有效不应期(AERP)，并分析AERP的频率适应性。结果 单纯注射生理盐水或奥美拉唑，AERP和其频率适应性无显著改变。心房快速起搏使生理盐水＋起搏组的AERP200及AERP150较起搏前显著缩短 (P<0.05)，频率适应性的指标（AERP200AERP150）/50 ms显著缩短 （P<0.01）。而奥美拉唑+起搏组的AERP和频率适应性未发生显著变化。结论 奥美拉唑对心房不应期无直接影响，但可有效防止心房快速起搏引起的心房电重构。
Abstract:
AIM To investigate the effects of proton pump inhibitor (PPI) Omeprazole on tachycardiainduced acute atrial electrical remodeling in rabbits. METHODS Twentyfour rabbits were randomly divided into 4 groups: normal saline (NS) group, Omeprazole group, NS + rapid pacing group and Omeprazole + rapid pacing group. 1∶1 rapidest atrial pacing was performed in the latter 2 groups following venous injection of NS and Omeprazole, respectively. Atrial effective refractory period was measured at basic cycle length of 200 and 150 ms before pacing and every 0.5 h after the onset of atrial pacing. RESULTS The AERP and the rate adaptation of AERP had no significant changes in normal saline (NS) group, Omeprazole group and Omeprazole + rapid pacing group while the AERP200 and AERP150 were remarkably shortened in NS+ rapid pacing group (P<0.05, vs. basic value). The rate adaptation of AERP was reversed through the pacing process in NS+ rapid pacing group (P<0.05, vs. basic value). CONCLUSION Omeprazole do not directly modify the AERP, but can attenuate the pacinginduced AERP shortening.

参考文献/References

［1］ Weigl M,Gschwantler M, Gatterer E, et al. Reflux esophagitis in the pathogenesis of paroxysmal atrial fibrillation: results of a pilot study［J］. Southern Med J,2003, 96(11):1128-1132.

［2］ Gordon J, Saleem SM, Ngaage DL, et al. Swallow syncope associated with paroxysmal atrial fibrillation［J］. Eur J Cardiothorac Surg,2002,21(3): 587-590.

［3］ Gerson LB, Friday K, Triadafilopoulos G. potential relationship between gastroesophageal reflux disease and atrial arrhythmias［J］. J Clin Gastroenterol, 2006,40(9):828-832.

［4］ Kim YH, Lim DS, Lee JH, et al. Gene expression profiling of oxidative stress on atrial fibrillation in humans［J］. Exp Mol Med, 2003, 35 (5) : 336-349.

［5］ Dudley SCJr, Hoch NE, McCann LA, et al. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases［J］. Circulation, 2005, 112(9): 1266-1273.

［6］ Kim YM, Guzik TJ, Zhang YH, et al. A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation［J］. Circ Res, 2005, 97（7）: 629-636.

［7］ Carnes CA, Chung MK, Nakayama T, et al. Ascorbate attenuates atrial pacinginduced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation ［J］. Circ Res, 2001, 89 ( 6 ) : E32-E38.

［8］ Lin PH, Lee SH, Su CP, et al. Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation ［J］. Free Radic Biol Med, 2003, 35(10) : 1310-1318.

［9］ 郑延松，李源，臧益民，等. 氧化应激对培养心肌细胞线粒体酶活性的影响［J］. 心脏杂志，2001，13 (5) : 346 - 347，351.

［10］单兆亮，王玉堂，时向民，等. 山羊持续性心房颤动模型的制作［J］. 心脏杂志, 2005, 17 (6) : 505- 507.

［11］Yamamoto E, Lai ZF, Yamashita T, et al. Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis［J］. J Hypertens, 2006, 24(10): 2057-2069.

备注/Memo

备注/Memo:
收稿日期：2007-01-19.通讯作者：王玉堂，主任医师，博士，主要从事心脏起搏与心脏电生理研究Email:wyt301@sina.com 作者简介：程晋芳，硕士生Email:chengjinfang_010@163.com
更新日期/Last Update: