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云南汉族人基质金属蛋白酶-1基因多态性与冠心病的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第1期
页码:
41-44
栏目:
临床研究
出版日期:
2008-01-20

文章信息/Info

Title:
Relationship between matrix metalloproteinase1 polymorphism and coronary heart disease in Han population in Yunnan
作者:
方勤1;  王启贤1;  刘华2;  邓东波1;  戴青原1 ; 张跃1
昆明医学院第一附属医院 ：1.心内科,2.检验科，云南 昆明 650032
Author(s):
FANG Qin1;  WANG Qixian1;  LIU Hua2;  DENG Dongbo1;  DAI Qingyuan1;  ZHANG Yue1
1.Department of Cardiology, 2.Department of Clinical Laboratory, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan, China
关键词:
基质金属蛋白酶-1;  基因多态性;  冠状动脉疾病
Keywords:
matrix metalloproteinase1; coronary heart disease;  genetic polymorphism
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究基质金属蛋白酶-1(matrix metalloproteinase-1,MMP-1)基因多态性与冠心病发病的关系。方法 用聚合酶链反应限制性片段长度分析法分析经冠脉造影确诊的98例冠心病患者MMP-1启动区域1607位点基因型，与同期102例非冠心病患者为对照组,比较两组之间MMP-1基因多态性频率分布的差异，并结合造影情况,探讨MMP-1基因多态性与冠脉狭窄程度的关系。结果 冠心病患者MMP-1基因 2G/2G 型（0.41)明显低于正常对照者(0.56), 差异有显著性(P<0.05)。 2G等位基因频率在冠心病组和对照组分别为0.61、0.72(P<0.05)；MMP-1基因 1607-G/2G位点多态性分布与冠脉狭窄程度差异无统计学意义。结论 MMP-1基因突变型（2G/2G）可能与冠心病遗传易感性有关。MMP-I基因-1607位点多态性与冠心病狭窄程度无关。
Abstract:
AIM To investigate the association between metalloproteinase-1 polymorphism and coronary heart disease (CHD). METHODS This study was conduced with casecontrol design in 98 patients with angiographically documented CHD and 102 control subjects with no coronary artery disease. The genotype was determined by polymerase chain reactionrestriction fragment length polymorphism for the common -1607 allele function promoter polymorphism of MMP-1 gene. The relationship between the polymorphism and the severity of coronary arterial stenosis was analyzed. RESULTS The result of individual polymorphisms analysis showed that the frequency of 2G/2G genotype in the patients (0.41) was significantly lower than that in control subjects (0.56). The frequency of allele1607 was respectively 0.61 and 0.72 in CHD group and control group (P<0.05). The frequency of 2G/2G genotype of 1607 polymorphism was not statistically different in CHD patients with one, two, three or more significantly diseased vessels. CONCLUSION Our findings suggest that 2G/2G genotype in MMP-1 promoter (-1607) influenced the susceptibility to CHD. The 1607 polymorphism is not a good predictor of the severity of coronary atherosclerosis.

参考文献/References

［1］ Sukhova GK,Schnbeck U,Rabkin E, et al. Evidence for increased collagenolysis by interstitial collagenasesl and 3 in vulnerable human atheromatous plaques ［J］. Circulation,I999,99 （19）：2503-2509.

［2］ Rutter JI， Mltcheli TI， Buttlce G， et al. A single nucleotide polymorphism in the metalloproteinase1 promoter creates an Ets binding site and augments transcription ［J］. Cancer Res，1998 ， 58（23）：5321-5325.

［3］ Fang S, Jin X, Wang R,et al . Polymorphisms in the MMP1 and MMP3 promoter and nonsmall call lung carcinoma in North China ［J］. Carcinogenesis,2005, 26（2）:481-486.

［4］ Galis ZS,Sukhova GK,Lark MW, et al .Increase expression of matrix metalloproteinase and matrix degrading activity in vulnerable region of human atherosclerotic plaques ［J］. J Clin Invest,1994,94(6):2493-2503.

［5］ Lemaitre V,O′Byrne TK,Borczuk AC,et al. ApoE knock out mice expression human matrix metalloproteinase1 in macrophages have less advance atherosclerosis ［J］ . J Clin Invest,2001,107(10):1227-1234.

［6］ Ye S,Gale CR, Martyn CN . Variation in the matrix metalloproteinase1 gene and risk of coronary heart disease［J］. Eur Heart J， 2003，24(2):1668-1671.

［7］ 姜红菊，张梅， 李大庆,等.冠心病患者基质金属蛋白酶1基因多态性［J］.中国动脉硬化杂志,2005,13（5）:589-592.

［8］ Wesley RB,Meng X,Godin D,et al .Extracellular matrix modulate macrophage function characteristic to atheroma : collagen type 1 enhance acquisition of resident macrophage traits by human peripheral blood monocytes in vitro［J］. Arterioscler Thromb Vasc Biol， 1998, 18(13):432-440.

［9］ Rocnik EF,Chan BM,Pickering JG. Evidence for a role of collagen synthesis in arterial smooth muscle cell migration ［J］. J Clin Invest, 1998.101(9):1889-1898.

［10］Galis ZS,Khatri JJ . Matrix metalloproteinase in vascular remodeling and atherogenesis :the good，the bad and the ugly ［J］. Circ Res,2002,90(3):2512-2562.

备注/Memo

备注/Memo:
收稿日期：2006-09-25.通讯作者：王启贤，副主任医师，博士，主要从事冠心病基础与临床研究Email:wqinxian@sina.com 作者简介：方勤，硕士生Email：fangqin2006@126.com
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