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|本期目录/Table of Contents|

不同支架对冠心病患者介入术后炎症因子的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第1期
页码:
55-57
栏目:
临床研究
出版日期:
2008-01-20

文章信息/Info

Title:
Effects of different intracoronary stents on level of inflammatory factors in patients with coronary heart disease after angioplasty
作者:
王临光1;  冯小平2
1.徐州市心血管病研究所心内科，江苏 徐州221009；2.青岛市海慈医疗集团检验中心，山东 青岛 266033
Author(s):
WANG Linguang1;  FENG Xiaoping2
1.Xuzhou Cardiovascular Disease Institute, Xuzhou 221009, Jiangsu, China; 2.Clinic laboratory Center, Qingdao Haici Medical Group, Qingdao 266033, Shandong, China
关键词:
药物支架; 细胞间黏附分子1; P选择素; 超敏C反应蛋白质; 白细胞介素6
Keywords:
drugeluting stents;  high sensitive Creactive protein;  interleukin6;  Pselectin;  soluble intercellular adhesion moleculeI
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 比较药物洗脱支架与普通支架植入前后冠心病患者血超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、P选择素（P-selectin）、可溶性细胞间黏附分子（sICAM-1）的变化，探讨其意义。方法 选择有支架植入指征的冠心病患者66例，随机分为药物支架组和普通支架组，30例置入支架Cypher（Cypher支架组），36例置入普通Bx sonic支架（普通支架组）。分别于手术前，术后即刻，术后6 h、术后24 h、7 d取肘静脉血, 采用ELASA法检测IL-6、P选择素、slCAM-1 、hs-CRP。结果 Cypher支架组与普通支架组比较P选择素、IL-6、slCAM-1、 hs－CRP水平在扩张前、术后即刻没有显著性差异,而术后6h、24h、7d时Cypher支架各测定值显著低于普通支架组（P<0.05,P<0.01）。结论 Cypher药物洗脱支架对冠心病患者介入术后血炎症因子的产生有抑制作用。
Abstract:
AIM To compare the effects between drug eluting stents and common stents in the levels of serum high sensitive Creactive protein (hsCRP), interleukin6 (IL6), plasma Pselectin and soluble intercellular adhesion moleculeI (sICAM1) in patients with coronary heart disease before and after angioplasty. METHODS Sixtysix patients following coronary angiograph were divided randomly into drugeluting stents implantment group (30 cases of Cypher stent implantment) and common stents implantment group (36 cases of common stent implantment). Peripheral venous blood samples were taken before, immediately after, at 6 h, at 24 h and 7 days after angioplasty. The levels of hsCRP, sICAM1, IL6 and Pselectin were analyzed by enzyme linked immunosorbent assay (ELASA). RESULTS Between the two groups no significant difference was found in the levels of hsCRP, sICAM1, IL6 and Pselectin before and immediately after angioplasty. At 6 hour, 24 hour and 7 day after angioplasty, the levels of hsCRP, sICAM1, IL6 and Pselectin were significantly lower in Cypher group than those in common stent group. CONCLUSION The Cypher drugeluting stents reduce the levels of inflammatory factors after angioplasty.

参考文献/References

［1］ SinoSIRIUS 研究组.国人应用雷帕霉素药物洗脱支架预防再狭窄的初步经验SinoSIRIUS临床试验［J］.中华心血管病杂志，2003,31(11):814-817.

［2］ Koenig W . Inflammation and coronary heart disease: an overview ［J］. Cardiol Rev, 2001,9(1): 31-35.

［3］ 吴永键, 宋光远, 杨跃进. 冠心病介入治疗中的药物支架(一)［J］. 中国医疗器械信息, 2005,11（2):45-46,50.

［4］ Inoue T, Hoshi K, Yaguchi I, et al. Serum levels of circulating adhesion molecules after coronary angioplasty［J］. Cardiology, 1999,91(4):236-242.

［5］ Suzuki T, Kopia G, Hayashi S, et al. Stent-based delivery of sirolimus reduces neointimal formation and instent restenosis in a porcine coronary model［J］. Circulation,2001,104(10): 1188-1193.

备注/Memo

备注/Memo:
收稿日期：2007-03-25 作者简介：王临光，副主任医师Email:Wanglinguang@medmail.com.cn
更新日期/Last Update: