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|本期目录/Table of Contents|

慢性心力衰竭患者心房颤动与白细胞介素-6、C反应蛋白和血管紧张素Ⅱ水平的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第4期
页码:
447-448，452
栏目:
临床研究
出版日期:
2008-08-20

文章信息/Info

Title:
Relationship between levels of IL6, CRP, AngⅡ and atrial fibrillation in patients with chronic heart failure
作者:
宋浩明; 罗明;  梁四维; 沈艺
同济大学附属同济医院心血管内科，上海 200065
Author(s):
SONG Haoming;  LUO Ming;  LIANG Siwei;  SHEN Yi
Department of Cardiovasology, Tongji Hospital, Tongji University, Shanghai 200065, China
关键词:
心力衰竭; 慢性; 心房颤动; 白细胞介素-6; C反应蛋白; 血管紧张素Ⅱ
Keywords:
chronic heart failure;  atrial fibrillation;  interleukin-6;  Creactive protein;  angiotensinⅡ
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 比较伴有心房颤动和窦性心律的慢性心力衰竭（CHF）患者白细胞介素6（IL6）、C反应蛋白（CRP）和血管紧张素Ⅱ(AngⅡ)水平变化，探讨其与CHF患者心房颤动中的关系。方法 选择已经治疗病情稳定的CHF患者67例(其中伴有心房颤动患者32例和窦性节律患者35例)，检测其IL6、CRP和AngⅡ水平,通过超声心动图测定CHF患者的左室射血分数。结果 伴有心房颤动患者的IL6、CRP和AngⅡ水平较窦性心律患者有显著差异。结论 炎症和肾素-血管紧张素-醛固酮系统与CHF患者的心房颤动有关联。
Abstract:
AIM To compare the levels of interleukin6 (IL6), Creactive protein (CRP) and angiotensinⅡ(AngⅡ) in chronic heart failure(CHF) patients with atrial fibrillation and CHF patients with sinus rhythm and to explore the effect of IL6, CRP and AngⅡ on the atrial fibrillation in the chronic heart failure patients. MEDTHODS The levels of IL6, CRP and AngⅡ were detected in sixtyseven stable chronic heart failure patients and left ventricular eject fraction (LVEF) was measured by echocardiography in all the patients. RESULTS The levels of IL6, CRP and AngⅡ in patients with atrial fibrillation were obviously higher than those in patients with sinus rhythm. CONCLUSION Both inflammation and Reninangiotensinaldosterone system may play some important roles in CHF patients with atrial fibrillation.

参考文献/References

［1］ Chugh SS, Blackshear JL, Shen WK, et al. Epidemiology and matural history of atrial fibrillation: clinical implications ［J］. J Am Coll Cardiol, 2001, 37(2)：371-378.

［2］ Aviles RJ, Martin DO, AppersonHansen C ,et al. Inflammation as a risk factor for atrial fibrillation ［J］. Circulation, 2003, 108(24):3006-3010.

［3］ Chung MK, Martin DO, Sprecher D, et al. Creactive protein elevation in patients with atrial arrgythmias: Inflammatory mechanisms and persistence of atrial fibrillation［J］. Circulation, 2001, 104(24):2886-2891.

［4］ Sata N, Hamada N, Horinouchi T, et al. Creactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation?［J］. Jpn Heart J, 2004, 45(3):441-445.

［5］ Watanabe T, Takeishi Y, Hirono O, et al. Creactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation ［J］. Heart Vessels, 2005, 20(2):45-49.

［6］ 贾新未,王晓娜,史红云,等.血浆肾素-血管紧张素-醛固酮水平对心房颤动转复的影响［J］. 心脏杂志， 2006, 18(5):547-549.

［7］ Healey JS, Morillo CA, Connolly SJ, et al. Role of the reninangiotensin aldosterone system in atrial fibrillation and cardiac remodeling［J］. Curr Opin Cardiol, 2005, 20(1):31-37.

备注/Memo

备注/Memo:
收稿日期：2007-02-01.作者简介：宋浩明，副主任医师，硕士 Email:songhaoming@163.com
更新日期/Last Update: