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芪丹通脉片对急性心肌梗死家兔心肌肌钙蛋白I的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第4期
页码:
398-402
栏目:
基础研究
出版日期:
2008-08-20

文章信息/Info

Title:
Effect of qidantongmai Tablet on cardiac troponin I of acute myocardial infarction in rabbits
作者:
肖茜1王宗仁1王超2彭道荣3马静1陈金钟1李晶华1
第四军医大学: 1.西京医院中医科,2.药物研究所,3.西京医院检验科,陕西 西安 710032
Author(s):
XIAO Qian1 WANG Zongren1 WANG Chao2 PENG Daorong3 MA Jing1 CHEN Jinzhong1 LI Jinghua1
1.Department of Traditional Chinese Medicine, Xijing Hospital, 2.Institute of Materia Medica, Department of Pharmacy, 3.Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
芪丹通脉片结扎冠状动脉心肌梗死家兔肌钙蛋白
Keywords:
qidantongmai tablet deligation coronary artery myocardial infarction rabbit cardiac troponin
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 观察芪丹通脉片(QDTMT)对结扎冠状动脉所致家兔心肌梗死后肌钙蛋白I的变化,探讨QDTMT作用于心肌梗死的机制。方法 采用结扎冠状动脉左旋支致家兔心肌梗死模型,观察灌胃给药14 d后QDTMP对心肌梗死的预防作用。结果 ①模型组家兔出现明显的心肌梗死,QDTMT各组心肌梗死程度与模型组比较,其病变程度显著减轻(P<001),心肌梗死面积缩小(P<001)。②光镜和电镜观察可见QDTMT能明显减轻家兔心肌病理损伤,改善心肌细胞超微结构。③心肌梗死后肌钙蛋白I升高,用QDTMT组肌钙蛋白I明显降低,用药组与模型组比较有显著差异(P<0.05或P<001)。结论 QDTMT对家兔结扎冠状动脉所致心肌梗死损伤具有明显的保护作用。
Abstract:
AIM To observe the effect of qidantongmai Tablet (QDTMT) on the changes of cardiac troponin I in rabbits following their death caused by ligationinduced acute myocardial infarction (AMI) and its mechanism. METHODS We observed the preventive effects of QDTMT on AMI after a 14day intrgastric QDTMT administration in the model of coronary artery left circumflex ligationinduced acute myocardial infarction. RESULTS ①Obvious myocardial infarction was found in the model group but myocardial infarction in QDTMT groups alleviated significantly (P<001) and the infarction area shrunk (P<001). ②Light microscope and electron microscope showed that QDTMT significantly reduced pathological injury in myocardium and improved the ultramicrostructure of cells. ③The content of cTnI significantly decreased in QDTMT groups, significantly different from that in the model group (P<005 or P<001). CONCLUSION QDTMT has obvious protective effect on myocardium in rabbits with ligationinduced acute myocardial infarction.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2008-02-08.基金项目:军队“十一五”中医药研发重大临床攻关课题项目资助(2006191001) 通讯作者:王宗仁,主任医师,主要从事心脑血管瘀症研究Email:zongren@fmmu.edu.cn 作者简介:肖茜,硕士生Email:xq_718@163.com
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