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血管紧张素-（1-7）改善急性心肌缺血/再灌注损伤家兔内皮功能及其超声评价(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第4期
页码:
420-423
栏目:
基础研究
出版日期:
2008-08-20

文章信息/Info

Title:
Effects of angiotensin-(1-7) pretreatment on endothelial function in rabbits with ischemicreperfusion injury
作者:
肖平喜; 裴兆辉; 曾武涛; 刘志军; 吴敬国; 何建桂; 马虹
广州中山大学附属第一医院心内科，广东 广州 510080
Author(s):
XIAO Pingxi;  PEI Zhaohui;  ZENG Wutao;  LIU Zhijun;  WU Jingguo;  HE Jiangui;  MA Hong
Department of Cardiology, First Affiliated Hospital, Sun Yatsen University, Guangzhou 510080, Guangdong, China
关键词:
血管紧张素-(1-7); 缺血-再灌注损伤; 内皮功能; 内皮依耐性舒张
Keywords:
angiotensin-(1-7);  ischemicreperfusion injury;  endothelial function;  endotheliumdepedent dilation
分类号:
Q541.3
DOI:
-
文献标识码:
A
摘要:
目的 探讨血管紧张素（Ang）-(1-7)对急性心肌缺血/再灌损伤（ischemicreperfusion injury，IRI）家兔内皮功能的影响。方法 建立家兔急性心肌IRI模型，将45只新西兰大白兔随机分为假手术组、IRI模型对照组及Ang-(1-7)组。分别于缺血/再灌注前后检测各组静脉血中一氧化氮（NO）、内皮素-1（ET-1）的含量。超声测量各组家兔肱动脉内皮依赖性舒张功能EDD（%）的变化。结果 模型对照组NO的含量及EDD（%）值较假手术组明显降低（P<0.05），ET-1的含量明显增高；Ang-(1-7)组NO含量及EDD（%）值较模型对照组明显升高（P<0.05），ET-1含量较对照组明显下降（P<0.05）。NO的含量与EDD（%）值有良好的相关性。结论 Ang-(1-7)预处理可以改善急性IRI期家兔内皮功能，肱动脉EDD是一种评价IRI家兔内皮功能的良好指标。
Abstract:
AIM To explore the effects of Ang-(1-7) on endothelial dysfunction in rabbits with ischemicreperfusion injury（IRI）. METHODS Myocardial ischemic reperfusion injury models were set up by ligating and loosening rabbits’ coronary artery. Fortyfive male New Zealand rabbits were randomly divided into shamoperation group, model control group and Ang-(1-7) group, which were treated respectively with intravenous infusion of Ang-(1-7) (25 mg/kg per hour) or saline after operation. The levels of plasma NO and endothelin-1 (ET-1) were determined under quiescent condition before and after the reperfusion. The endothelium dependent dilation (EDD(%)), that would represent the endothelial function, was evaluated with the aid of ultrasonoscope. RESULTS The levels of plasma NO and EDD(%) in model control group were significantly lower than those in shamoperation group（P<0.05）. The level of ET-1 was significantly higher than that in model control group（P<0.05）. Compared with those in model control group, the levels of NO and EDD(%) in Ang-(1-7) group were significantly higher （P<0.05） and ET-1 was lower （P<0.05）. A positive correlation was found between NO level and EDD(%) value and a negative correlation was found between ET-1 level and EDD(%) value. CONCLUSION Pretreatment with Ang-(1-7) improves vascular endothelial function at acute stage in rabbits suffering from IRI, which can be appropriately evaluated by brachial artery's EDD.

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备注/Memo

备注/Memo:
收稿日期：2007-06-12.基金项目：广东省自然基金项目资助（04300348） 通讯作者：马虹，教授，主要从事冠心病及心律失常方面的研究Email：sumsmahong@21cn.com 作者简介：肖平喜，主治医师，博士生Email:sysuxiao@163.com
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