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氯沙坦对原发性高血压患者脉压及血管内皮功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第4期
页码:
432-435
栏目:
临床研究
出版日期:
2008-08-20

文章信息/Info

Title:
Effects of losartan on pulse pressure and endothelial function in patients with essential hypertension
作者:
樊民; 丁茹; 任雨笙; 黄佐
第二军医大学附属长征医院心内科，上海 200003
Author(s):
FAN Min;  DING Ru;  REN Yusheng;  HUANG Zuo
Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
关键词:
氯沙坦; 高血压; 原发性; 脉压; 血管内皮
Keywords:
losartan; hypertension;  essential;  pulse pressure;  endothelial function
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨氯沙坦对原发性高血压患者脉压（PP）及血管内皮功能的影响。方法 将56例原发性高血压患者按照平均脉压大小分为PP≥60 mmHg组（27例）、PP<60 mmHg组（29例），分别予以氯沙坦50～100 mg/d口服治疗24周，采用高分辨率超声系统检测肱动脉血流介导的血管舒张反应（FMD）评价血管内皮功能，比较两组治疗前后血压、脉压、血管内皮功能的变化。结果 PP≥60 mmHg组患者FMD受损程度较PP<60 mmHg组更为显著（P<005）；氯沙坦治疗24周后，两组患者脉压均有所降低（P<001）、FMD均有所改善（P<001），而较之PP<60 mmHg组，PP≥60 mmHg组患者脉压的降低及FMD的改善更为显著（P<005）。结论 脉压增大可能加重原发性高血压患者的血管内皮功能障碍，氯沙坦在降低血压的同时可以降低脉压，改善血管内皮功能，脉压大的患者获益更多。
Abstract:
AIM To explore the effects of losartan on pulse pressure and endothelial function in patients with essential hypertension (EH). METHODS A total of 56 hypertensive patients were divided into two groups: PP≥60 mmHg group (n=27) and PP<60 mmHg group (n=29). Patients in both groups were treated with losartan 50-100 mg once daily for 24 weeks. The brachial artery flowmediated dilation (FMD) was measured with the highresolution ultrasonography to assess the endothelial function. Differences of PP and endothelial function between the two groups were measured before and after treatment. RESULTS FMD of patients in PP≥60 mmHg group was lower than that in PP<60 mmHg group (P<005). FMD and PP of patients in both groups were significantly improved after treatment (P<005), but FMD and PP in PP≥60 mmHg group were improved more significantly compared with those in PP<60 mmHg group (P<005). CONCLUSION Losartan decreases PP and improves endothelial dysfunction in patients with EH. Patients with greater PP may benefit more from losartan treatment.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-01-30.基金项目：上海市自然科学基金项目资助（03ZR14029） 通讯作者：黄佐,副主任医师，主要从事冠心病基础和临床研究 Email:huangzuob@yahoo.com.cn 作者简介：樊民，主治医师，博士Email:fanmin@medmail.com.cn
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