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血管紧张素（1-7）对两种模型高血压大鼠心功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第6期
页码:
668-672
栏目:
基础研究
出版日期:
2008-12-25

文章信息/Info

Title:
Effect of Angiotensin (1-7) on left and right cardiac function in two hypertensive models
作者:
于学军; 何作云; 黄岚; 王晓燕
第三军医大学新桥医院全军心血管内科中心，重庆 400037
Author(s):
YU Xuejun;  HE Zuoyun;  HUANG Lan;  WANG Xiaoyan
Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
血管紧张素（1-7）; 高血压; 压力超负荷; 肾素-血管紧张素-醛固酮系统; 心功能
Keywords:
angiotensin(1-7);  hypertension;  reninangiotensinaldosterone system;  pressure overload hypertension;  cardiac function
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨血管紧张素（1-7）［Ang(1-7)］对单纯压力负荷增加及肾素-血管紧张素-醛固酮系统(RAAS)激活的高血压模型左右心室收缩及舒张功能的影响及其机制。方法 建立肾下主动脉缩窄（INAC）及二肾一夹（2K1C）模型，应用微渗泵植入技术，使Ang（1-7）进行不同时间（14及28 d）的体内干预，采用经颈动脉插入心导管法检测这两种高血压模型左室和右室收缩及舒张功能。结果 在2K1C动物模型，建模同时及术后14 d应用Ang（1-7），均可有效降低血压,平均下降15%～20%(P<0.05）。在INAC动物模型，建模同时应用Ang（1-7），在术后第14天时血压下降13.6%（P<0.05）；术后14 d开始应用Ang（1-7），血压下降7.9%。在2K1C模型，14 d时其左室收缩功能无明显变化，但其舒张功能则已受损，Ang（1-7）可使其显著改善（-dp/dtmax,P<0.05）；术后42 d，2K1C组的收缩与舒张功能均明显受损；Ang（1-7）可使其收缩功能显著改善（+dp/dtmax，P<0.05），但对其舒张功能则改善不明显（-dp/dtmax，LVDEP）。在2K1C模型的右室，14 d时收缩及舒张功能均已受损，Ang（1-7）可使其显著改善［2K1C组比Ang（1-7）组，+dp/dtmax，-dp/dtmax，P<0.05］；术后第42天，右室的收缩与舒张功能受损更为明显，Ang（1-7）使其收缩功能显著改善（+dp/dtmax，P<0.05），对其舒张功能则改善不明显（-dp/dtmax）。在INAC动物模型，14 d时其左室收缩和舒张功能均无明显变化；42 d时，其舒张功能有所降低（-dp/dtmax，P<0.05），Ang（1-7）可使其明显改善（-dp/dtmax，P<0.05）。14及42 d时，其右室收缩与舒张功能均无明显变化，Ang（1-7）对其亦无明显影响。结论 Ang(1-7)可改善高血压模型左室和右室收缩及舒张功能。但对两种模型的改善程度不同，且与其降压效果不同步，提示Ang(1-7)对心功能的改善可能具有多种作用机制。
Abstract:
AIM To determine the effect of Angiotensin (1-7) on the left and right cardiac function in the pressureoverload hypertensive model (Infranephric aorta coarctation, INAC) and RAAS acitivation hypertensive model（Two kidney one clip, 2K1C）. METHODS We established INAC and 2K1C hypertensive models and examined the parameters representing the blood pressure and cardiac function. RESULTS ①In the 2K1C hypertensive model, Ang(1-7) effectively decreased the systolic blood pressure, beginning at 3 rd day, reaching to peak at 7-12 th day and remaining to 28 th day, with an average of 15%-20% (P<0.05). In the INAC model, Ang(1-7) effectively prevented the systolic blood pressure elevation when used together with the operation (decreasing by 13.6%, P<0.05), but it had no significant effect on the SBP when used 14 days after operation (decreasing by 7.9%); ②In the 2K1C model, continual and serious deterotation was observed in both the left and right ventricular functions especially in the diastolic function. Ang(1-7) as used in early stage of hypertension improved all the functions［2K1C group compared with Ang（1-7） group, +dp/dtmax, -dp/dtmax, P<0.05］. Ang(1-7) as used in the late stage of hypertension only improved the systolic function［2K1C group compared with Ang（1-7） group, +dp/dtmax, P<0.05］. In the INAC model, a left ventricular diastolic function decrease was observed only in the late stage of hypertension and the Ang(1-7) restored it efficiently（-dp/dtmax, P<0.05）. CONCLUSION Ang(1-7) can effectively improve the left and right cardiac function, but not syncronize with the SBP decrease. The degree of improvement is different in the two hypertensive models as well as in left and right ventricles, which indicates there are diferent mechanisms in the effect of Ang(1-7) on the improvement of cardiac function.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2007-10-22.基金项目：国家教育部博士后基金项目资助（2002A068） 作者简介：于学军，副主任医师Email：yxuejun2003＠yahoo.com.cn
更新日期/Last Update: 2009-03-24