曲美他嗪对异丙肾上腺素所致大鼠心肌肥厚的影响(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2008年第6期
- 页码:
- 701-703
- 栏目:
- 基础研究
- 出版日期:
- 2008-12-25
文章信息/Info
- Title:
- Effects of trimetazidine on cardiac hypertrophy induced by isoprenaline in rats
- Author(s):
- LIANG Lihua1; JIANG Shan2
- 1.Department of Cardiology, Liaoning electric power centre hospital, Shenyang 110015, Liaoning, China; 2.Department of Cardiology, First Affiliated Hospital, Liaoning Medical College, Jinzhou 121001, Liaoning, China
- Keywords:
- isoprenaline; cardiac hypertrophy; energy metabolism; trimetazidine
- 分类号:
- R542.2
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 探讨曲美他嗪（TMZ）对异丙肾上腺素(ISO)致大鼠心肌肥厚的影响及可能的作用机制。方法 30只SpragueDdwley（SD）大鼠，随机分为3组。正常对照组、ISO组、TMZ组，每组10只。通过大剂量注射ISO制成心肌肥厚模型，以 TMZ干预，观察心肌组织病理学变化和心肌细胞超微结构改变，计算心脏质量/体质量（HW/BW），测定心肌三磷酸腺苷（ATP）、丙二醛（MDA）、超氧化物歧化酶（SOD）和血清乳酸脱氢酶（LDH）、肌酸激酶（CK）含量。结果 TMZ组与ISO组比较，HW/BW、LDH、 CK、SOD和ATP有显著差异（P<0.05），而与正常对照组比较无显著差异。TMZ组心肌组织病理损伤程度及细胞超微结构改变程度，较ISO组明显减轻，而接近正常对照组。结论 TMZ可拮抗ISO所致的大鼠心肌肥厚，其机制可能与改善心肌能量代谢、提高组织对缺氧的耐受力、消除氧自由基等有关。
- Abstract:
- AIM To investigate the effects of trimetazidine (TMZ) on cardiac hypertrophy induced by isoprenaline (ISO) in rats and the mechanisms. METHODS Thirty SpragueDdwley（SD） rats were divided randomly into normal control group, ISO group and TMZ group. Rat myocardial hypertrophy models were established by subcutaneous injection of isoproterenol, except normal control group and pathological and ultrastructure changes of myocardial muscle were observed by optical and electron microscope. Heart weight/body weight（HW/BW）, the contents of superoxide dismutase（SOD）, malondialdehyde（MDA） and adenosine 5’triphosphate （ATP） in myocardial muscle and the activities of lactate dehydrogenase（LDH） and creatine kinase（CK） in serum were measured. RESULTS Significance difference was found between TMZ group and ISO group in HW/BW, LDH, CK, SOD and ATP（P<0.05）, while no statistical significance was found between TMZ group and normal control group. Compared with that in ISO group, the degree of myocardial damage In TMZ group was significantly reduced, close to that in normal control group. CONCLUSION TMZ reduces cardiac hypertrophy induced by isoprenaline in rats, possibly due to the improved energy metabolism in the heart and reduced oxygen free radical.
参考文献/References
［1］ Bruckner BA, Razeghi P, Stetson S, et al. Degree of cardiac fibrosis and hypertrophy at time of implanutation predicts myocardial improvement during left ventricular assist device support［J］. J Heart Lung Transplant, 2004, 23(1):36-42.
［2］ Tarone G, Guido G. Molecular interplay between mechanical and humoral signaling in cardiac hypertrophy［J］. Trends Mol Med, 2003, 9(9):376-382.
［3］ Rona G, Chappel CI, Balazs T, et al. An infactlike myocardial lesion and other toxic manifestations produced by isoproterenol in the rat\[J\]. AMA Arch Pathol, 1959, 67(4):443-455.
［4］ Acharya Dhan Kumar, 党瑜华. 曲美他嗪在缺血性心脏病中的应用［J］. 中国临床药理学与治疗学, 2006, 11(4):385-391.
［5］ 赵艳芳, 秦永文, 王学敏, 等. 曲美他嗪对大鼠缺血再灌注心肌线粒体的保护作用［J］. 中国动脉硬化杂志 , 2005, 13(2):171-174.
［6］ 徐静,何作云,冯兵，等. 曲美他嗪对肥大心肌细胞缺氧复氧的抗凋亡作用［J］. 重庆医学, 2006, 35(10):909-911,913.
备注/Memo
- 备注/Memo:
- 收稿日期：2006-12-01.作者简介:梁丽华，医师，硕士生Email:llHgzm_2005@126.com
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