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氟伐他汀对冠心病患者PAPP-A和ox-LDL水平的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第6期
页码:
711-713
栏目:
临床研究
出版日期:
2008-12-25

文章信息/Info

Title:
Effect of fluvastatin on PAPPA and oxLDL levels in patients with coronary heart disease
作者:
蔡高军1; 王凌燕2; 何国平1; 柏庆利11
1.江苏大学附属武进医院心内科,江苏 常州 213000； 2.吉林大学中日联谊医院心内科,吉林 长春 130031
Author(s):
CAI Gaojun1;  WANG Lingyan2;  HE Guoping1;  BAI Qingli1
1.Department of Cardiology, Affiliated Wujin Hospital, Jiangsu University, Changzhou 213000, Jiangsu, China; 2.Department of Cardiology, ChinaJapan Union Hospital affiliated to Jilin University, Changchun 130031, Jilin, China
关键词:
妊娠相关血浆蛋白A; 氧化型低密度脂蛋白; 冠状动脉疾病
Keywords:
pregnancyassociated plasma proteinA;  oxidized lowdensity lipoprotein;  coronary disease
分类号:
R972.6
DOI:
-
文献标识码:
A
摘要:
目的 观察氟伐他汀治疗对冠心病患者妊娠相关血浆蛋白-A(PAPP-A)和氧化型低密度脂蛋白(ox-LDL)水平的影响。方法 选择冠心病组患者75例,包括急性心肌梗死(AMI)患者32例，不稳定型心绞痛(UAP)患者22例和稳定型心绞痛(SAP)患者21例。正常对照组60例。采用双抗体夹心酶联免疫吸附试验检测冠心病患者PAPP-A和ox-LDL水平。结果 PAPP-A在急性冠脉综合征组(ACS,包括AMI、UAP)浓度较SAP及正常对照组均明显偏高(P<0.05)；ox-LDL在冠心病组中的浓度较正常对照组高(P<0.05)，且在AMI、UAP、SAP各组组间比较均有显著性差异(P<0.05)；氟伐他汀治疗后冠心病患者PAPP-A和ox-LDL浓度均显著下降(P<0.01)；PAPP-A与ox-LDL水平呈正相关(P<0.01)。结论 氟伐他汀治疗后冠心病患者PAPP-A和ox-LDL浓度降低，氟伐他汀可能通过抑制炎症反应，减少氧化应激来发挥心血管的保护作用。
Abstract:
AIM To observe the effect of fluvastatin on PAPP-A and ox-LDL levels in patients with coronary heart disease. METHODS Seventyfive patients with coronary heart disease were divided into acute myocardial infarction (n=32), unstable angina pectoris (n=22) and stable angina pectoris (n=21) groups, and 60 subjects without coronary disease were used as controls. The serum PAPP-A and ox-LDL were detected by ELISA. RESULTS The level of PAPP-A in acute coronary syndrome (ACS, including acute myocardial infarction and unstable angina pectoris) patients was significantly higher than those in stable angina pectoris patients and controls (P<0.05). The level of ox-LDL in patients with coronary heart disease was significantly higher than that in controls (P<0.05), with significant difference between AMI, UAP and SAP groups (P<0.05). After the treatment with fluvastatin, the levels of PAPP-A and ox-LDL markedly decreased (P<0.01) and the level of PAPPA was positive correlated with that of ox-LDL (P<0.01). CONCLUSION After fluvastatin treatment, the levels of PAPP-A and ox-LDL greatly decrease in coronary heart disease group. Fluvastatin has a protective effect on heart by repressing inflammatory reaction and attenuating oxidative stress.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2007-09-13. 作者简介:蔡高军,住院医师,硕士Email:cgj982@126.com
更新日期/Last Update: 2009-03-24