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螺内酯抑制急性前壁心肌梗死患者的左室重构(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第6期
页码:
749-751
栏目:
临床研究
出版日期:
2008-12-25

文章信息/Info

Title:
Spironolactone inhibits the left ventricular remodeling in patients with acute anterior myocardial infarction
作者:
赵依农; 吾红光; 邱慧卿; 胡军; 郑彦
衢江区人民医院心内科，浙江 衢州 324000
Author(s):
ZHAO Yinong;  WU Hongguang;  QIU Huiqing;  HU Jun;  ZHENG Yan
Department of Cardiology, Qujiang People’s Hospital, Quzhou 324000, Zhejiang, China
关键词:
心肌梗死; 前壁; 急性; 左室重构; 螺内酯
Keywords:
acute anterior myocardial infarction;  left ventricular remodeling;  spironolactone
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨急性前壁心肌梗死患者口服螺内酯对于左室重构的影响。方法 将急性前壁心肌梗死患者随机分为两组。对照组30例，接受血管紧张素转换酶抑制剂、β受体阻滞剂、抗血小板、调脂药物等常规处理。螺内酯组30例，在常规治疗基础上加用螺内酯（40 mg，每日1次）。随访1年，并检测脑钠尿肽（BNP）及超声心动图以评价左室功能和左室容积。结果 6和12月时螺内酯组血清BNP水平明显低于对照组［（355±74）ng/L vs (418±77)ng/L,P<0.05和(316±72)ng/L vs (389±67)ng/L,P<0.05］，且12月时螺内酯组较对照组左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)明显缩小［LVEDD：(49±6)mm vs (53±5)mm,P<0.05;LVESD：(37±5)mm vs (40±4)mm,P<0.05］。结论 螺内酯可抑制急性前壁心肌梗死患者左室重构。
Abstract:
AIM To investigate the effect of Spironolactone on the left ventricular remodeling（LVRM） in patients with acute anterior myocardial infarction. METHODS Sixty patients with (AMI) were randomly divided into two groups by stratified random sampling. Thirty patients in contrast group received regular treatments of angiotensin converting enzyme inhibitor (ACEI), βreceptor blocker, plus antiplatelet and lowering lipid drugs while 30 patients in experimental group were given Spironolactone (40 mg, qd) on the basis of the treatment in contrast group. During a oneyear followup, plasma BNP levels were measured with eletrochemistry luminescent technique and echocardiogram was performed to evaluate the left ventricular function and volume. RESULTS The plasma BNP levels in experimental group decreased significantly compared with those in contrast group at the 6th and at the 12 th month ［（355±74）ng/L vs (418±77)ng/L, P<0.05 and (316±72)ng/L vs (389±67)ng/L, P<0.05］. The lift ventricular enddiastolic diameter(LVEDD) and lift ventricular endsystolic diameter(LVESD) at the 12 th month in experimental group decreased significantly compared with those in contrast group. ［LVEDD: (49±6)mm vs (53±5)mm, P<0.05; LVESD: (37±5)mm vs (40±4)mm, P<0.05］. CONCLUSION pironolactone inhibits LVRM in patients with acute anterior myocardial infarction.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-02-11.作者简介：赵依农，副主任医师Email：qzz1964@163.com
更新日期/Last Update: 2009-03-24