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|本期目录/Table of Contents|

单纯性肥胖症患者外周血ghrelin、obestatin的水平变化及其临床意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
95-98
栏目:
临床研究
出版日期:
2009-02-28

文章信息/Info

Title:
Study on circulating levels of ghrelin and obestatin in human simple obesity
作者:
徐海蓉1; 2; 郑兴1; 郭志福1
1.第二军医大学长海医院心内科，上海 200433；2．武警新疆总队医院心内科，新疆 乌鲁木齐 830000
Author(s):
XU Hai-rong1; 2;  ZHENG Xing1;  GUO Zhi-fu1
1.Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2.Department of Cardiovascular Diseases, General Hospital, Xinjiang Armed Police Corps, Urumchi 830000, Xinjiang, China
关键词:
脑肠肽激素; 肥胖抑制素; 肥胖症
Keywords:
ghrelin;  obestatin;  obesity
分类号:
R587.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨单纯性肥胖症患者餐前、餐后外周血肥胖抑制素（obestatin）水平的变化及其与ghrelin（一种脑肠肽激素）间的关系。方法 采用放射免疫法（RIA）检测16例单纯性肥胖症患者和14例正常对照者餐前1 h及其中各10例餐后2 h外周血ghrelin、obestatin水平；同时采用酶联免疫分析法（ELISA）检测餐前胰岛素水平并监测体质量指数（BMI）、腰臀比、血糖、血脂、白细胞及超敏C反应蛋白。结果 单纯性肥胖症患者餐前外周血ghrelin和obestatin水平均低于正常对照组（均P<0.01），但ghrelin/obestatin比值却明显高于正常对照组（P<0.01）。单纯性肥胖症组和正常对照组餐后ghrelin/obestatin比值均明显低于其餐前（分别P<0.05，P<0.01），但两组间差异无统计学意义。相关分析显示餐前ghrelin/obestatin比值与BMI（r=0.54，P<0.01）、腰围（r=0.39，P<0.05）、总胆固醇（r=0.40，P<0.05）和低密度脂蛋白胆固醇（r=0.41，P<0.05）呈正相关；与其它指标间相关性无统计学意义。结论 餐前外周血ghrelin、obestatin间比例失衡可能是单纯性肥胖症的发病机制之一。
Abstract:
AIM To investigate preprandial and postprandial changes of circulating ghrelin and obestatin levels in simple obesities. METHODS Plasma ghrelin and obestatin concentrations 1 hour before meal were measured by radioimmunoassay in 16 simple obese adolescents and 14 normal controls. Body mass index, waist-hip ratio, plasma glucose, plasma insulin, blood lipids, white blood cells count and high sensitive C-reactive protein were measured. Plasma ghrelin and obestatin concentrations 2 hours after meal were measured in 10 of the simple obese adolescents and 10 of the controls. RESULTS Although both prepramdial plasma ghrelin (P<0.01) and obestatin (P<0.05) concentrations decreased in simple obesities as compared with those in normal controls (both P<0.01), their ratios of ghrelin to obestatin were increased (P<0.01) even after adjustment for gender and age. The ratios of postprandial ghrelin to postprandial obestatin decreased both in simple obesities (P<0.05) and normal controls (P<0.01) compared with their preprandial ratios, but the postprandial ratios were similar between simple obesities and normal controls. There were significant positive correlations respectively between prepramdial ghrelin/obestatin and BMI (r=0.54, P<0.01), waist circumference (r=0.39, P<0.05), total cholesterol (r=0.40, P<0.05), low-density lipoprotein cholesterol (r=0.41, P<0.05). CONCLUSION The imbalance of prepramdial circulating ghrelin and obestatin may play a role in the pathogenesis of human obesity.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-3-11.通讯作者：郑兴，主任医师，主要从事冠心病的治疗研究Email:XingZheng@126.com 作者简介：徐海蓉，副主任医师Email:ligang_xian@126.com
更新日期/Last Update: 2009-04-02