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|本期目录/Table of Contents|

心包积液患者心包液中CGRP和内皮素水平与积液量和心功能有关

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
102-104
栏目:
临床研究
出版日期:
2009-02-28

文章信息/Info

Title:
Study of CGRP and ET-1 in pericardiac fluid of patients with pericardiac effusion
作者:
孔祥权; 杨玉雯; 汪祥海; 阚敬保; 徐承华; 范剑锋
皖南医学院附属弋矶山医院心内科，安徽 芜湖 241001
Author(s):
KONG Xiang-quan;  YANG Yu-wen;  WANG Xiang-hai;  KAN Jing-bao;  XU Cheng-hua;  FAN Jian-feng
Department of Cardiology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui, China
关键词:
心包积液; 心包液; 降钙素基因相关肽; 内皮素
Keywords:
pericardiac effusion;  pericardiac fluid;  calcitonin gene-related;  endothelin
分类号:
R542.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨心包积液患者心包液中降钙素基因相关肽（CGRP）、内皮素（ET-1）与积液量、心功能的关系。方法 35例心包积液患者按NYHA标准分为心功能Ⅲ、Ⅳ级，行超声心动图检查，计算积液量。行经皮穿刺心包腔内留置导管引流术时，取心包液及静脉血。正常对照组（血浆）30例。用放射免疫分析法测定心包液和血浆中CGRP、ET-1的浓度。 结果 心包液CGRP、ET-1的浓度显著高于血浆中的浓度（P<0.01），血浆中CGRP、ET-1含量较正常对照组明显升高（P<0.01），且心包液和血浆中CGRP、ET-1水平均与心功能相关（分别为P<0.01和P<0.05），心包液中CGRP、ET-1浓度与积液量呈正相关（分别为r=0.43、r=0.38，P<0.05）。结论 心包积液患者心包液中CGRP、ET-1的浓度与心功能、积液量密切相关。
Abstract:
AIM To investigate the relationship between cardiac function, volume of pericardiac fluid (PF) and ET-1 and CGRP in the PF of patients with pericardiac effusion. METHODS The volume of PF was measured by echocariography in 35 patients with pericardiac effusion (NYHA class Ⅲ, Ⅳ). ET-1 and CGRP levels in PF and serum were detected by RIA and compared with those in serum in 30 healthy subjects. RESULTS Both ET-1 and CGRP levels in PF were significantly higher than those in serum (P<0.01) in patients with pericardiac effusion and the serum ET-1 and CGRP levels in patents with pericardiac effusion were significantly higher than those in control group. ET-1 and CGRP levels in PF and serum were related to the cardiac function (P<0.01, P<0.05, respectively). ET-1 and CGRP levels were positively related to the volume of PF (r=0.43, 0.38, respectively, P<0.05). CONCLUSION ET-1 and CGRP levels in PF are closely related to the cardiac function and the volume of PF in patients with pericardiac effusion.

参考文献/References

[1］ Mebazaa A, Wetzel RC, Dodd-o JM, et al. Potential paracrine role of the pericardium in the regulation of cardiac function［J］ . Cardiovasc Res, 1998, 40(2):332-342.
［2］ 王士雯，钱方毅. 老年心脏病学［M］. 第2版. 北京： 人民卫生出版社， 1998:556-566.
［3］ Parlapiano C, Paoletti V, Campana E, et al. CGRP and ET-1 plasma levels in normal subjects［J］. Eur Rev Med Pharmacol, 1999, 3(3):139-141.
［4］ 陈良海, 罗兴林, 李刚. 降钙素基因相关肽和内皮素在充血性心力衰竭中的作用［J］. 临床心血管病杂志, 1998, 14(3):146-147.
［5］ Mann DL. Inflammatory mediators and the failing heart: past, present, and the foreseeable future［J］. Circ Res, 2002, 91(11):988-998.
［6］ Torre-Amione G, Young JB, Durand J, et al. Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class Ⅲ to Ⅳ congestive heart failure［J］. Circulation, 2001, 103(7):973-980.
［7］ 温绍君,王耀宏,王卫梅,等. 心脏病患者心功能与心包液中心钠素和内皮素浓度的关系［J］. 中华心血管病杂志, 2000, 28(5):377-378.
［8］ Bucinskaite V, Brodda-Jansen G, Stenfors C, et al. Increased concentrations of Calcitonin gene-related peptide-like immunoreactivity in rat brain and peripheral tissue after ischaemia: correlation to flap survival［J］. Neuropeptides, 1998, 32(2):179-183.
［9］ Filippelli A, Falciani M, Piucci B, et al. Endothelin-1 affects capsaicin-evoked release of neuropeptides from rat vas deferens［J］. Eur J Pharmacol, 1999, 364(2-3):183-191.

备注/Memo

备注/Memo:
收稿日期：2008-6-18.通讯作者：杨玉雯，主任医师，主要从事心功能不全的临床和 基础研究Email:yangyuwen@yahoo.com.cn 作者简介：孔祥权，硕士生Email:kong.dylan@yahoo.com.cn
更新日期/Last Update: 2009-04-02