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|本期目录/Table of Contents|

Toll样受体4在心肌缺血/再灌注损伤中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
117-118121
栏目:
综述
出版日期:
2009-02-28

文章信息/Info

Title:
-
作者:
耿小勇; 秦明照
首都医科大学附属北京同仁医院干部医疗科，北京 100730
Author(s):
-
关键词:
Toll样受体4; 心肌; 缺血/再灌注损伤
Keywords:
-
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
近年来Toll样受体及其在缺血/再灌注损伤中的作用日益引起人们关注，本文就近年来此方面的相关进展作一综述。
Abstract:
-

参考文献/References

[1］ Sabroe I, Read RC, Whyte MK, el al. Toll-like receptors in health and disease: complex questions remain［J］. J Immunol, 2003, 171(4):1630-1635.
［2］ Gobert AP, Bambou JC., Werts C, et al. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentia-tion factor 88-independent mechanism［J］. J Biol chem, 2004, 279(1):245-250.
［3］ Triantafilou M, Triantafilou K. Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide［J］. Biochem Soc trans, 2004, 32(Pt 4):636-639.
［4］ Zhao ZQ, Zang YM. Alternative cardioprotective strategy during reperfusion: postconditioning vs preconditioning［J］. 心脏杂志， 2006,18(1):1-7,13.
［5］ Chong AJ, Shimamoto A, Hampton CR, et al. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart［J］. J Thorac cardiovasc surg, 2004, 128(2):170-179.
［6］ Li C, Ha T, Kelley J, et al. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection［J］. Cardiovasc res, 2004, 61(3):538-547.
［7］ Mullarkey M, Rose JR, Bristal J, et al. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist［J］. J pharmacol exp ther, 2003, 304(3):1093-1102.
［8］ Wong YN, Rossignol D, Rose J R, et al. Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study［J］. J clin pharmacol, 2003, 43(7):735-742.

备注/Memo

备注/Memo:
收稿日期：2007-6-1.通讯作者：秦明照，教授，主要从事冠心病和动脉粥样硬化的 研究Email:qinmingzhao@gmail.com 作者简介：耿小勇，主治医师，硕士生Email:hbsjzgxy@163.com
更新日期/Last Update: 2009-04-02