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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2009年第2期

页码:

242-243/247

栏目:

临床研究

出版日期:

2009-03-30

文章信息/Info

Title:

Changes of superoxide dismutase and trace elements in different types of heart failures

作者:

蔡春¹; 常耀明²; 高双斌³; 王伯良⁴

第四军医大学：1.西京医院预防保健科，2.航空航天医学系，3.预防医学系 营养与食品卫生学教研室，4.唐都医院急诊科，陕西 西安 710032

Author(s):

CAI Chun¹;  CHANG Yao-ming²;  GAO Shuang-bin³;  WANG Bo-liang⁴

1.Department of Prevention and Heath Care, Xijing Hospital, 2.School of Aerospace and Aviation Medicine, 3.Department of Preventive Medicine, 4.Department of Emergency Medicine, Tangdu Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China

关键词:

心力衰竭; 超氧化物歧化酶; 微量元素

Keywords:

heart failure;  superoxide dismutase;  trace element

分类号:

R541.61

DOI:

-

文献标识码:

A

摘要:

目的 了解充血与缺血性心力衰竭（HF）时超氧化物歧化酶（SOD）及其相关微量元素细胞内外变化特征，为HF患者微量元素治疗提供依据。方法 用放射免疫法测定27例急诊HF患者维生素C抗氧化治疗前后血清SOD，用日立180-80原子吸收分光光度计测定血浆及红细胞内外微量元素Cu，Zn，Se，Fe。结果 充血性HF(CHF)与缺血性心脏病伴心功能不全患者［缺血性HF(IHF)］及二者与正常组比较SOD均无显著差异。CHF治疗前后红细胞Se，Fe，Cu与正常组比较差异显著（P<0.01），治疗前后血浆Zn降低、Cu升高，与正常组比较差异显著（P<0.01）。治疗前血浆Se与正常组比较降低且有显著差异（P<0.05）。IHF治疗前后红细胞Se，Fe，Cu与正常组比较均降低且差异显著（P<0.01），治疗前后血浆Cu升高、Zn降低,与正常组比较差异显著（P<0.01）。IHF红细胞治疗后较治疗前Cu升高、Zn降低（均P<0.05）。IHF治疗前血浆Cu低于CHF组（P<0.05）。结论 经维生素C抗氧化治疗血清SOD水平可接近正常水平，但危重HF患者与SOD相关微量元素代谢明显紊乱，尚需根据CHF与IHF不同特征补充微量元素。

Abstract:

AIM To investigate the changes of superoxide dismutase (SOD) and trace elements in patients with congestive heart failure (CHF) or ischemic heart failure (IHF) before and after vitamin C treatment. METHODS Blood SOD and trace element levels were analyzed in 27 cases of emergence CHF and IHC subjects and the results were compared before and after vitamin C treatment. RESULTS No significant difference in serum SOD levels was observed between CHF and IHF. CHF group had much lower Se, Fe, and Cu in red blood cells compared to those in normal subjects (P<0.01). Plasma levels of Cu, Zn, Se had significant difference compared with those in normal subjects (P<0.05, P<0.01) before and after vitamin C treatment. In IHF group, Se, Fe, Cu levels of red blood cell were significant lower than those in normal subject (P<0.01) and significant difference was found in the plasma levels of Cu and Zu compared with those in normal subjects (P<0.01) before and after vitamin C treatment. Cu and Zu in red blood cell were significantly increased and decreased post-treatment (P<0.05). CONCLUSION SOD level can be maintained close to normal after vitamin C treatment in patients with CHF or IHF. Trace element supplement should be provided for disorder of SOD-related trace element in patients with serious heart failure.

参考文献/References

[1］ 张雅君，徐仲卿，郑建春，等. 老年男性冠心病患者血液中一氧化氮、一氧化氮氧合酶和超氧化歧酶水平临床分析［J］. 中国老年保健医学杂志， 2006， 4（3）：12-13.

［2］ 杨欣国，李波. 心力衰竭的程度分类和危重度心衰的诊断和治疗［J］. 心脏杂志， 2005， 17（1）：89-90.

［3］ Turnlund JR, Keen CL, Smith RG. Copper status and urinary and salivary copper in young men at three levels of dietary copper［J］. Am J Clin Nutr, 1990, 51(4):658-664.

［4］ 程义勇，蒋与刚. 生物医学微量元素数据手册［M］. 天津: 天津科学技术出版社, 1994：45-47.

［5］ Turnlund JR, Jacob RA, Keen CL, et al. Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men［J］. Am J Clin Nutr, 2004, 79(6):1037-1044.

［6］ 赵先英，刘毅敏，覃军，等. 微量元素硒、锰、氟对SOD活性的影响［J］. 第三军医大学学报， 2004， 26（2）：171-173.

备注/Memo

备注/Memo:

收稿日期：2008-6-17.基金项目：唐都医院院级课题资助（院研9028） 通讯作者：常耀明，教授，主要从事微量元素与营养研究Email:changym@fmmu.edu.cn 作者简介：蔡春，副主任医师Email:caichun@fmmu.edu.cn

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更新日期/Last Update: 2009-04-16