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Title:: Randomized controlled trial of the therapeutic effect of qidantongmai tablet against hyperlipidemia

作者:: 李晶华¹; 邵中军²; 王宗仁¹; 马静¹; 肖铁卉¹; 第四军医大学： 1.西京医院中医科，2.军事预防医学系流行病学教研室，陕西西安 710032

Author(s):: LI Jing-hua¹; SHAO Zhong-jun²; WANG Zong-ren¹; MA Jing¹; XIAO Tie-hui¹; 1.Department of Chinese Traditional Medicine, Xijing Hospital, 2.Department of Epidemiology, School of Preventive Medicine, Fourth Military Medical University, Xian 710032, Shaanxi, China

关键词:: 芪丹通脉片; 随机对照试验; 高脂血症

Keywords:: qidantongmai tablet; randomized controlled trial; hyperlipidemia

分类号:: R559

DOI:: -

文献标识码:: A

摘要:: 目的探讨复方中药芪丹通脉片（QDTMT）治疗高脂血症的临床疗效。方法以社区高脂血症235例老年人为研究对象，按随机、对照、单盲设计临床试验。将入选对象随机分为QDTMT组、血脂康组和安慰剂组。分别采集研究对象试验前、后外周血并检测血清总胆固醇（TC）、三酰甘油（TG）和高密度脂蛋白胆固醇（HDL-C），分析QDTMT对高脂血症的治疗效果。结果与安慰组相比，QDTMT、血脂康能降低TC和TG，升高HDL-C含量（均P<0.05）；QDTMT与血脂康疗效无显著差异。结论 QDTMT治疗高脂血症有效，其疗效与血脂康无显著差异。

Abstract:: AIM: To determine the therapeutic effects of qidantongmai tablet (QDTMT) against hyperlipidemia. METHODS: We designed a randomized controlled single-blind study. Two hundred and thirty five elderly hyperlipidemic subjects were enrolled and randomized into QDTMT group, Xuezhikang group and placebo group. Serum was withdrawn from subjects and total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDLC) were detected at the beginning and at the end of the study. Therapeutic effects of QDTMT against hyperlipidemia were analyzed based on the above data. RESULTS: In comparison with placebo, TC and TG were significantly reduced in QDTMT and Xuezhikang groups, and HDLC was significantly increased in QDTMT group (P<0.05). There was no significant difference between QDTMT and Xuezhikang groups. CONCLUSION: QDTMT is an effective medicine against hyperlipidemia.

参考文献/References

［1］ Jain KS, Kathiravan MK, Somani RS, et al. The biology and chemistry of hyperlipidemia［J］. Bioorg Med Chem, 2007, 15(14):4674-4699.

［2］龙铟,王宗仁,马静,等. 芪丹通脉片对大鼠血栓形成及血液粘度的影响［J］. 微循环学杂志, 2006, 16(1): 37-39.

［3］王宗仁,刘建勋,尚晓泓,等. 活血通脉片对实验性心肌缺血梗死犬血液生化指标的影响［J］. 第四军医大学学报, 1999, 20(10):907-909.

［4］牟乃洲,王晓屏,徐艳春,等. 茶色素对高脂血症患者血液流变性和甲襞微循环的影响［J］. 中国血液流变学杂志, 1999, 1(9)56-59.

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［6］马世平,章梅,王宗仁,等. 活血通脉片对高血压患者血脂、血液流变和细胞流变性的临床疗效观察［J］. 第四军医大学学报, 2000, 21(3):292-294.

［7］李晶华,王宗仁,邵中军,等. 芪丹通脉片对实验性急性心肌梗死大鼠心肌的保护作用及其分子机制［J］. 中国临床康复, 2004, 8(9):1706-1707.

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