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Title:: -

作者:: 张晓卉¹; 刘越¹; 张改改¹; 马骁²; 尹新华¹; 哈尔滨医科大学附属第二医院:1.心内科，2.消化科,黑龙江哈尔滨 150086

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关键词:: Ghrelin; 心血管效应; 作用机制

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分类号:: R972

DOI:: -

文献标识码:: A

摘要:: Ghrelin是一种体内生长激素促分泌素受体的内源性配体,其除了能促进生长激素分泌外，在体内许多器官系统还发挥着重要作用。Ghrelin在心血管系统中的作用，包括:改善内皮细胞功能失调、抗心肌细胞凋亡、增加射血分数、扩张外周血管和减轻心脏缺血/再灌注损伤等。现重点阐述ghrelin的心血管效应及其作用机制。

Abstract:: -

参考文献/References

［1］ Xu X, Jhun BS, Ha CH, et al. Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation［J］. Endocrinology, 2008, 149(8):4183-4192.

［2］ Zhao H, Liu G, Wang Q, et al. Effect of ghrelin on human endothelial cells apoptosis induced by high glucose［J］. Biochem Biophys Res Commun, 2007, 362(3):677-681.

［3］ Li A, Cheng G, Zhu GH, et al. Ghrelin stimulates angiogenesis in human microvascular endothelial cells: Implications beyond GH release［J］. Biochem Biophys Res Commun, 2007, 353(2):238-243.

［4］ Iantorno M, Chen H, Kim JA, et al. Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells［J］. Am J Physiol Endocrinol Metab, 2007, 292(3):E756-E764.

［5］ Li W, Gavrila D, Liu X, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-κB activation in human endothelial cells［J］. Circulation, 2004, 109(18):2221-2226.

［6］ Zhang M, Yuan F, Chen H, et al. Effect of exogenous ghrelin on cell differentiation antigen 40 expression in endothelial cells［J］. Acta Biochim Biophys Sin(Shanghai), 2007, 39(12):974-981.

［7］ Nagaya N, Moriya J, Yasumura Y, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure［J］. Circulation， 2004, 110(24)：3674-3679.

［8］ Pemberton C, Tokola H, Bagi Z, et al. Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion［J］. Am J Physiol Heart Circ Physiol, 2004, 287(4):H1522-H1529.

［9］ Grossini E, Molinari C, Mary DA, et al. Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs［J］. Endocrinology, 2007, 148(2):806-812.

［10］Soeki T, Kishimoto I, Schwenke DO, et al. Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction［J］. Am J Physiol Heart Circ Physiol, 2008, 294(1):H426-H432.

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Ghrelin的心血管效应及作用机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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