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|本期目录/Table of Contents|

高脂血症患者血压变异性与动脉血管弹性的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第5期
页码:
689-692,705
栏目:
临床研究
出版日期:
2009-07-14

文章信息/Info

Title:
Blood pressure variability and arterial elasticity in hyperlipidemic patients
作者:
刘松岩1; 李毓忠1; 周建中2;  翟艳辉1; 宫磊1
1.武警新疆总队医院急诊科，新疆 乌鲁木齐 830091； 2.兰州军区乌鲁木齐总医院干部病房，新疆 乌鲁木齐 830000
Author(s):
LIU Song-yan1;  LI Yu-zhong1;  ZHOU Jian-zhong2;  ZHAI Yan-hui1;  GONG Lei1
1.Emergency Department, Hospital of Xinjiang Municipal Corps, Chinese Peoples Armed Police Forces, Ulumuqi 830091, Xinjiang, China; 2.Cadres Ward, Urumuqi General Hospital, Lanzhou Military Area Command, Urumuqi 830000, Xinjiang, China
关键词:
动态血压监测; 动脉顺应性; 血压变异性; 冠状动脉疾病; 高脂血症
Keywords:
ambulatory blood pressure monitoring;  arterial compliance;  blood pressure variability;  coronary disease;  hyperlipidemia
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 通过对高脂血症总胆固醇(TC)/高密度脂蛋白胆固醇(HDL-C)比率>5.0患者与健康人群比较，探讨高脂血症的血压变异性（BPV）和动脉顺应性的关系。方法: 高脂血症患者33例和血脂代谢正常的健康体检者33例，记录24 h动态血压监测(ABPM)和测量动脉顺应性，两组间经年龄、性别、体质量配对后比较。 结果: 高脂血症患者组24 h收缩期BPV［(20±6)mmHg vs (16±4)mmHg,P<0.01,1 mmHg=0.133 kPa］、舒张期BPV ［(17±5)mmHg vs (14±5)mmHg,P<0.05］和平均动脉压的BPV［(16±5)mmHg vs (13±5)mmHg, P<0.05］明显高于血脂代谢正常的健康体检者。两组间大、小动脉顺应性无显著性差异；健康对照者24 h收缩期BPV与大动脉顺应性呈显著负相关(r=-0.46,P<0.05)。而两组受试者24 h、白天及夜间的BPV与小动脉的顺应性无相关性。结论: 高脂血症患者BPV比血脂代谢正常的健康体检者高，但高脂血症患者大动脉顺应性与收缩压无相关性。
Abstract:
AIM: To study the relationship between blood pressure variability (BPV) and arterial compliance in hyperlipidemic subjects, which was defined as total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) of >5.0 as compared to normolipidemic subjects. METHODS: Thirty-three hyperlipidemic patients were age- gender- and weight-matched with normolipidemic controls. Twenty-four-hour ambulatory blood pressure monitoring was recorded and arterial compliance was measured. RESULTS: There were significantly higher 24-h systolic ［(20±6) mmHg vs.(16±4) mmHg, P<0.01, 1 mmHg=0.133kPa］, diastolic ［(16±5)mmHg vs.(13±5)mmHg, P<0.05］ and mean arterial ［(16±5)mmHg vs.(13±5)mmHg, P<0.05］ BPVs in the hyperlipidemic group as compared to those in the normolipidemic group. There were no significant differences in large and small arterial compliance among groups. In normolipidemic subjects, there was a significant inverse relationship between 24-h systolic BPV and large arterial compliance (r=0.46, P<0.05). No significant correlations were found between small arterial compliance and the 24-h BPV, daytime BPV and night-time BPV analyses in subjects of both groups. CONCLUSION: BPV is higher in hyperlipidemic patients as compared to normolipidemic subjects. Large arterial compliance is negatively correlated with SBP in hyperlipidemic patients.

参考文献/References

［1］ Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study［J］. Circulation, 2002, 105(3):310-315.

［2］ 中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南［J］. 中华心血管病杂志, 2007, 35(5):390-419.

［3］ 鄢盛恺,周新,范侠,等. 关于临床血脂测定的建议［J］. 中华检验医学杂志, 2003, 26(3):182-184.

［4］ 动脉功能临床研究协作组. 中国健康人群动脉弹性功能参数研究［J］. 中华心血管病杂志， 2003, 31(4):245-249.

［5］ Syeda B, Gottsauner-Wolf M, Denk S, et al. Arterial compliance: a diagnostic marker for atherosclerotic plaque burden?［J］. Am J Hypertens, 2003, 16(5 Pt 1):356-362.

［6］ Grey A, Bratteli C, Glasser SP, et al. Reduced small artery but not large artery elasticity is an independent risk marker for cardiovascular events［J］. Am J Hypertens, 2003, 16(4):265-269.

［7］ Dart AM, Gatzka CD, Cameron JD, et al. Large artery stiffness is not related to plasma cholesterol in older subjects with hypertension［J］. Arterioscler Thromb Vasc Biol, 2004, 24(5):962-968.

［8］ Li Z, Mao HZ, Abboud FM, et al. Oxygen-derived free radicals contribute to baroreceptor dysfunction in atherosclerotic rabbits［J］. Circ Res, 1996, 79(4):802-811.

［9］ Pikkujms SM, Huikuri HV, Airaksinen KE, et al. Heart rate variability and baroreflex sensitivity in hypertensive subjects with and without metabolic features of insulin resistance syndrome［J］. Am J Hypertens, 1998, 11(5):523-531.

［10］Melenovsky V, Wichterle D, Simek J, et al. Effect of atorvastatin and fenofibrate on autonomic tone in subjects with combined hyperlipidemia［J］. Am J Cardiol, 2003, 92(3):337-341.

［11］Beswick A, Brindle P. Risk scoring in the assessment of cardiovascular risk［J］. Curr Opin Lipidol, 2006, 17(4):375-386.

备注/Memo

备注/Memo:
收稿日期：2008-5-20.作者简介:刘松岩,副主任医师Email:lsyone@126.com
更新日期/Last Update: 2009-07-22