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|本期目录/Table of Contents|

支架植入术对急性冠脉综合征炎症过程的影响及其与再狭窄的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
826-827，837
栏目:
临床研究
出版日期:
2009-11-05

文章信息/Info

Title:
Variance of IL-6, IL-10, and MMP-1 in patients with acute coronary syndrome after percutaneous coronary intervention and the interrelation of cytokines and restenosis
作者:
邓孟球; 吴先明
益阳市中心医院心血管内科，湖南 益阳 413000
Author(s):
DENG Meng-qiu;  WU Xian-ming
Department of Cardiology, Centry Hospital of Yiyang, Yiyang, Hunan 413000, China
关键词:
急性冠脉综合征; 经皮冠脉介入治疗; 白细胞介素6; 白细胞介素10; 基质金属蛋白酶1
Keywords:
acute coronary syndrome;  percutaneous coronary intervention;  interleukin-6;  interleukin-10;  matrix metalloproteinase-1
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨急性冠脉综合征（ACS）患者经支架植入术（PCI）后对血清IL-6、IL-10和基质金属蛋白酶1（MMP-1）的影响及再狭窄与各炎症因子的关系。方法: 选取ACS行冠脉支架植入术患者64例，并于术前、术后不同时间段分别采取外周静脉血，测定血清IL-6、IL-10、MMP-1的浓度，跟踪随访6个月，对冠脉再狭窄患者进行统计。结果: 冠脉支架植入术后IL-6、MMP-1浓度明显高于术前，24 h达到高峰，IL-6于术后1周、MMP-1于术后1个月降至术前水平；冠脉再狭窄组术前、术后24 h IL-6、MMP-1浓度明显高于非再狭窄组。结论: 冠脉支架植入术增加了血清炎症因子的水平，并能对冠脉再狭窄进行预测。
Abstract:
AIM: To detect the variance of IL-6, IL-10, and MMP-1 in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and the interrelation of cytokines and restenosis. METHODS: Serum concentrations of IL-6, IL-10 and MMP-1 were measured in 64 patients with ACS. Pre- and post-PCI was done by enzyme-linked immunosorbent assay (ELISA), and patients were followed-up after 6 months. RESULTS: Serum concentrations of IL-6 and MMP-1 significantly increased after PCI. When comparing the restenosis group to the no-restenosis qroup, they are different both pre- and post-PCI. CONCLUSION: Serum inflammatory levels were augmented by PCI and may predict restenosis.

参考文献/References

［1］ Li JJ, Xu B, Yang YJ, et al. Is there delayed restensosis in patients with coronary artery disease treated with sirolimus-eluting stent?［J］. Coron Artery Dis, 2007, 18（4）: 293-298.

［2］ Li JJ, Li Z, Li J. Is inflammation a contributor for in-stent restenosis?［J］. Med Hypotheses, 2007, 68（5）:945-951.

［3］ Blum A, Schneider DJ, Sobel BE, et al. Endothelial dysfunction and inflammation after percutaneous coronary intervention［J］. Am J Cardiol, 2004, 94（11）:1420-1423.

［4］ Versaci F, Gaspardone G. Prevention of restenosis after stenting: the emerging role of inflammation［J］. Coron Artery Dis, 2004, 15（6）:307-311.

［5］ Li JJ, Fang CH, Jaing H, et al. Increased C-reactive protein level after renal stent implantation in patients with atherosclerotic renal stenosis［J］. Angiology, 2004, 55（5）:479-484.

［6］ Hojo Y, Ikeda U, Katsuki T, et al. Interleukin-6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis［J］. Heart, 2000, 84（1）:83-87.

［7］ Sardella G, Mariani P, D’Alessandro M, et al. Early elevation of interleukin-1beta and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina［J］. Thromb Res, 2006, 117（6）:659-664.

P51［8］ Ezhov MV, Sumarlkov AB, Raimbekova IR, et al. Interleukin 6 but not interleukin 10 is associated with restenosis after coronary stenting［J］. Atherosclerosis, 2003, 169(1):193-194.

备注/Memo

备注/Memo:
收稿日期：2008-12-25.作者简介：邓孟球，主治医师，硕士Email:demeqi@126.com
更新日期/Last Update: 2009-09-30