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|本期目录/Table of Contents|

吸入NO对婴幼儿体外循环中肺表面活性物质的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
865-867
栏目:
临床研究
出版日期:
2009-11-05

文章信息/Info

Title:
Effects of inhaled nitric oxide on pulmonary surfactant during cardiopulmonary bypass in infants
作者:
杨顺章1; 刘海波1; 吴伟平1; 张志孟1; 张光磊2
1.福建医科大学附属泉州第一医院心外科,福建 泉州 362000；2.泉州市儿童医院小儿外科,福建 泉州 362000
Author(s):
YANG Shun-zhang1;  LIU Hai-bo1;  WU Wei-ping1;  ZHANG Zhi-meng1;  ZHANG Guang-lei2
1.Department of Cardiovascular Surgery, Quanzhou First Hospital, Quanzhou 362000, Fujian, China; 2.Department of Pediatric Surgery, Quanzhou Children’s Hospital, Quanzhou 362000, Fujian, China
关键词:
体外循环; 肺表面活性物质; 一氧化氮
Keywords:
cardiopulmonary bypass;  pulmonary surfactant;  nitric oxide
分类号:
R541.1;R654.1
DOI:
-
文献标识码:
A
摘要:
目的: 探讨吸入一氧化氮(NO)对婴幼儿体外循环（cardiopulmonary bypass，CPB）中肺表面活性物质的影响。 方法: 将30例患室间隔缺损的婴幼儿随机分为对照组和NO组，NO组在CPB期间吸入40 μl/L NO直至关胸。CPB前、主动脉开放后1，5，10 min以少量生理盐水灌洗气道，分别测定气道吸出物(BAL)中总磷脂(TPL)、饱和卵磷脂(SatPC)、总蛋白(TP)值，并计算SatPC/TPL和SatPC/TP。结果: CPB后两组SatPC/TPL、SatPC/TP较CPB前明显降低(P<0.01)。NO组SatPC/TPL和SatPC/TP下降的幅度明显小于对照组(P<0.01)。结论: 婴幼儿CPB术中存在明显的肺损害，表现为一些亚临床性肺功能损伤。吸入40 μl/L的NO对CPB期间肺功能有明显的保护作用。
Abstract:
AIM: To study the effects of inhaled Nitric Oxide (NO) on pulmonary function and pulmonary surfactant during cardiopulmonary bypass in infants. METHODS: Thirty infants with congenital heart disease with the high degree of PH were randomly divided into two groups: control group (n=15) and NO group (n=15). From throughout the cardiopulmonary bypass（CPB）, 40 μl/L NO was inhaled in NO group. Before CPB and at 1, 5 and 10 min after aortic declamping, air tube was lavaged by small amounts of normal saline, the levels of TPL, SatPC and TP were determined and the values of SatPC/TPL and SatPC/TP were calculated. RESULTS: The levels of SatPC/TPL and SatPC/TP post-operation were lower than those before CPB (P<0.01) and the decreased formants of SatPC/TPL and SatPC/TP in control group were higher than those in NO group. CONCLUSION: Lung ischemia-reperfusion injury is obvious during CPB in infants and manifests as sub-clinical pulmonary function injury. Inhale 40 μl/L NO has marked protective effect on the lung function during CPB.

参考文献/References

［1］ 段大为,陈德凤,张铁柱,等. 婴幼儿体外循环术后的并发症分析［J］． 中国现代医学杂志, 2001, 11(7):106-108.

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［9］ Koksoy C, Kuzu MA, Ergun H, et al. Intestinal ischemia and reperfusion impairs vasomotor functions of pulmonary vascular bed［J］. Ann Surg, 2000, 231(1):105-111.

备注/Memo

备注/Memo:
收稿日期：2008-12-4.基金项目：福建泉州市科技计划项目课题（2005Z14） 通讯作者：刘海波,副主任医师,主要从事心血管病的临床与基础研究Email:lhb2233.hot@163.com 作者简介：杨顺章,住院医师Email:yxz351@163.com
更新日期/Last Update: 2009-09-30