我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

内皮脂酶与动脉粥样硬化的关系及意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
872-874,889
栏目:
综述
出版日期:
2009-11-05

文章信息/Info

Title:
-
作者:
方玉强 综述黄岚 审校
第三军医大学新桥医院心内科全军心血管病研究所,重庆 400037
Author(s):
-
关键词:
内皮脂酶高密度脂蛋白动脉粥样硬化
Keywords:
-
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
内皮脂酶(EL)是新发现的脂酶成员,其主要作用是高密度脂蛋白(HDL)代谢的关键酶,但也参与其它脂蛋白的代谢。除代谢酶的催化作用外,它还通过桥联作用参与脂蛋白与细胞黏附。本文就EL的生物学特性、参与动脉粥样硬化的基础等进行综述。
Abstract:
-

参考文献/References

[1] Paradis E, Clavel S, Julien P, et al. Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia[J]. Neurobiol Dis, 2004, 15(2):312-325.

[2] Yu KC, David C, Kadambi S, et al. Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice[J]. J Lipid Res, 2004, 45(9):1614-1623.

[3] Jaye M, Krawiec J. Endothelial lipase and HDL metabolism[J]. Curr Opin Lipidol, 2004, 15(2):183-189.

[4] Kratky D, Zimmermann R, Wagner EM, et al. Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue[J]. J Clin Invest, 2005, 115(1):161-167.

[5] Gauster M, Rechberger G, Sovic A, et al. Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine[J]. J Lipid Res, 2005, 46(7):1517-1525.

[6] Sovic A, Panzenboeck U, Wintersperger A, et al. Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier[J]. J Neurochem, 2005, 94(1):109-119.

[7] 郑莺,刘建平. 糖尿病致冠状动脉粥硬化的机制[J]. 心脏杂志, 2007, 19(3):347-350.

[8] 杨大春,周兴文,速晓华,等. 同型半胱氨酸对血管内皮细胞E-选择素、IL-6分泌的影响[J]. 心脏杂志, 2006, 18(1):57-59.

[9] 张俊峰,葛恒,郭炳诗,等. PPARα配体对泡沫细胞炎性介质分泌的影响[J]. 心脏杂志, 2006, 18(3):262-264,268.

[10]陆卫忠,李玉英,余时沧,等. Canstatin基因转染对体外培养血管内皮细胞增殖与凋亡的影响[J]. 心脏杂志, 2006, 18(3):265-268.

[11]杨晓云,周宁,王琳,等. 辛伐他汀对NF-κB-DNA结合性和表达的影响[J]. 心脏杂志, 2006, 18(4):369-372.

[12]李铁,谭小进. 几丁聚糖防治动脉粥样硬化的机制[J]. 心脏杂志, 2006, 18(6):724-726.

[13]Tschernatsch MM, Mlecnik B, Trajanoski Z, et al. LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells[J]. Atherosclerosis, 2006, 189(2):310-317.

[14]方玉强,黄岚,宋耀明,等. 循环内皮细胞中内皮脂肪酶的表达与冠心病患者临床表现的关系[J]. 中华老年心脑血管病杂志, 2006, 8(12):812-814.

[15]Ahmed W, Orasanu G, Nehra V, et al. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion[J]. Circ Res, 2006, 98(4):490-498.

[16]Ishida T, Choi SY, Kundu RK, et al. Endothelial lipase modulates susceptibility to atheroscler- osis in apolipoprotein-E-deficient mice[J]. J Biol Chem, 2004, 279(43):45085-45092.

[17]Kojma Y, Hirata K, Ishida T, et al. Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation[J]. J Biol Chem, 2004, 279(52):54032-54038.

[18]Broedl UC, Jin W, Rader DJ. Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation[J]. Trends Cardiovasc Med, 2004, 14(5):202-206.

[19]Shimokawa Y, Hirata K, Ishida T, et al. Increased expression of endothelial lipase in rat models of hypertension[J]. Cardiovasc Res, 2005, 66(3):594-600.

[20]Badellino KO, Wolfe ML, Reilly MP, et al. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis[J]. PLoS Med, 2006, 3(2):e22.

备注/Memo

备注/Memo:
收稿日期:2007-9-19.作者简介:方玉强,主治医师,博士Email:yuqfang@163.com
更新日期/Last Update: 2009-09-30