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|本期目录/Table of Contents|

H2S调节心血管功能的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
878-881
栏目:
综述
出版日期:
2009-11-05

文章信息/Info

Title:
-
作者:
陈超; 倪鑫
第二军医大学生理学教研室，上海 200433
Author(s):
-
关键词:
硫化氢; 心脏; 血管
Keywords:
-
分类号:
R331.36
DOI:
-
文献标识码:
A
摘要:
越来越多的证据支持H2S是第三种内源性气体信号分子。内源性H2S以半胱氨酸为底物在胱硫醚-β-合成酶或胱硫醚-γ-裂解酶催化下生成。在心血管系统中，H2S作用于血管平滑肌KATP通道和Cl-/HCO-3交换体舒张血管，并参与血压中枢调节。此外，H2S促进血管平滑肌的凋亡并抑制其增殖。H2S也作用于心肌KATP通道调节心肌收缩。病理状态下，H2S参与多种心血管疾病的发生，如高血压、心肌缺血/再灌注损伤，外源性的H2S可减轻疾病程度。
Abstract:
-

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-11-17.作者简介：陈超，本科生Email:chen_chao88@yahoo.cn
更新日期/Last Update: 2009-09-30